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Table 2 Crude and adjusted associations between blood lipids and variants by race/ethnicity - NHANES III (1991-1994)

From: Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey

Genetic Variant

Non-Hispanic White

Non-Hispanic Black

Mexican American

SNP X Race/ethnicity

 

β (95% CI)

FDR-adjusted P value*

β (95% CI)

FDR-adjusted P value

β (95% CI)

FDR-adjusted P value

FDR-adjusted P value

Crude Analysis

       

High-density lipoprotein cholesterol

       

rs854560 (PON1)

-2.23

(-5.15,0.69)

0.3589

-0.58

(-2.81,1.65)

0.869

3.59

(1.55,5.64)

0.0308

0.2552

Low-density lipoprotein cholesterol

       

rs7412 (APOE)

-16.68

(-27.85,-5.50)

0.1144

-20.58

(-29.12,-12.04)

<.0001

-19.80

(-33.33,-6.28)

0.066

0.8931

Total serum cholesterol

       

rs7412 (APOE)

-13.90

(-25.39,-2.41)

0.1569

-16.26

(-25.75,-6.77)

0.0374

-10.26

(-19.18,-1.33)

0.2871

0.9227

Triglycerides

       

rs5918 (ITGB3)

0.05

(-0.06,0.17)

0.7294

0.14

(0.07,0.20)

0.0066

-0.05

(-0.17,0.06)

0.613

0.4653

Adjusted Analysis**

       

High-density lipoprotein cholesterol

       

rs854560 (PON1)

-1.53

(-4.11,1.06)

0.5062

-0.09

(-2.20,2.02)

0.9733

3.21

(1.45,4.97)

0.022

0.1535

Low-density lipoprotein cholesterol

       

rs7412 (APOE)

-16.87

(-27.94,-5.81)

0.0968

-22.52

(-30.01,-15.04)

<.0001

-21.47

(-31.32,-11.62)

0.0022

0.9012

rs429358 (APOE)

8.26

(1.19,15.33)

0.264

3.85

(-2.14,9.84)

0.6169

10.54

(6.41,14.67)

<.0001

0.9012

rs1799983 (NOS3)

3.05

(-2.41,8.52)

0.5284

5.28

(-0.42,10.98)

0.4103

-4.56

(-7.63,-1.48)

0.0396

0.9012

Total serum cholesterol

       

rs7412 (APOE)

-15.26

(-26.16,-4.36)

0.0902

-20.68

(-28.90,-12.47)

<.0001

-12.54

(-19.89,-5.20)

0.0198

0.9724

rs429358 (APOE)

9.82

(2.96,16.69)

0.0902

4.35

(-2.30,11.01)

0.6839

11.18

(7.11,15.25)

<.0001

0.9724

Triglycerides

       

rs5918 (ITGB3)

0.02

(-0.07,0.11)

0.8985

0.14

(0.09,0.19)

<.0001

-0.01

(-0.14,0.11)

0.8962

0.4419

  1. β, beta coefficient; CI, confidence interval; FDR, false discovery rate
  2. *P-value was based on Satterthwaite-adjusted F test and adjusted for multiple comparisons using false discovery rate within each race/ethnicity group.
  3. **Adjusted for age, sex, education, body mass index, smoking status, alcohol intake, physical activity, dietary fat intake.
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