BMC Medical Genetics

Table 2 Results of the single SNP association analysis of a 470 kb region on 2q11.2 in hand OA study sample.

From: Allelic variants of IL1R1gene associate with severe hand osteoarthritis

		Controls	Hand OA
				p-values
Gene	SNP	MAF	MAF	χ²	Pseudomarker
I	rs740044	0.178	0.155	0.507^a	0.517
	rs4141134	0.269	0.250	0.635^a	0.327
*IL1R2*	rs719250	0.182	0.177	0.867	0.382
	rs3218934	0.406	0.456	0.246	0.086
	rs3218984	0.394	0.424	0.472	0.185
II	rs1008394	0.394	0.439	0.281	0.083
	rs2310173	0.304	0.351	0.226	0.370
*IL1R1*	rs1465325	0.195	0.119	0.022 ^a	0.005
	rs956730	0.260	0.204	0.140^a	0.026
	rs3917225	0.396	0.309	0.043	0.078
	rs2287047	0.249	0.159	0.013 ^a	0.0009 ^b
	rs3771200	0.411	0.453	0.312	0.539
*IL1RL2*	rs2241132	0.158	0.141	0.644^a	0.491
	rs870684	0.378	0.394	0.690	0.781
	rs1922290	0.377	0.420	0.304	0.495
	rs1922295	0.379	0.400	0.613	0.696
	rs1997502	0.353	0.318	0.375	0.681
	rs2302612	0.119	0.157	0.199^a	0.505
III	rs1558626	0.446	0.488	0.313	0.108
	rs1345302	0.447	0.414	0.428	0.205
	rs1882510	0.224	0.229	0.919^a	0.517
	rs1420089	0.154	0.151	1.000^a	1.000
*IL1RL1*	rs1997466	0.476	0.427	0.250	0.385
	rs1041973	0.202	0.173	0.458^a	0.202
	rs12905	0.274	0.235	0.293	0.366
*IL18R1*	rs2287037	0.383	0.416	0.433	0.461
	rs2270298	0.265	0.189	0.081^a	0.131
	rs1035130	0.277	0.241	0.338	0.453
	rs1420096	0.466	0.458	0.868	0.746
*IL18RAP*	rs1420106	0.192	0.200	0.832^a	0.454
	rs1420100	0.469	0.447	0.599	1.000
	rs917997	0.189	0.185	1.000^a	0.990

MAF = Minor allele frequency in the sample set
χ² = p-values from Pearson's χ² analysis of allele difference between cases and controls
Pseudomarker = p-values of the family-based association analysis with Pseudomarker (dominant mode of inheritance)
I, II and III = three intergenic regions
^a = calculated with Fisher's test
^b = p-value remained statistically significant after correcting for multiple testing

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