Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease

BMC Medical Genetics

Table 5 Summary of NFE2L2 haplotypes that influence risk of PD

*NFE2L2*Haplotypes¹	Swedish material		Swedish material		Polish material
	Disease Risk (OR/allele)²	p-value³	AAO (Years/allele)	p-value³	Disease risk (OR/allele)²	p-value³
*Tag SNPs 2-6*
GAAAA	0.9 (0.6-1.3)	0.450	+4.8	7 × 10 ^-4	0.6 (0.4-0.9)	0.005
GAGGG	2.4 (1.2-4.5)	0.007	-0.1	0.952	0.9 (0.5-1.5)	0.699
GAAAG	3.7 (1.3-10.6)	0.010	-3.3	0.236	0.5 (0.2-1.6)	0.239
*Promoter P1-P3*
AGC	0.9 (0.7-1.3)	0.538	+2.1	0.061	0.6 (0.4-0.9)	0.003
*Full haplotypes* ⁴
GAGCAAAA	0.9 (0.6-1.4)	0.631	+4.6	0.001	0.4 (0.3-0.6)	2 × 10 ^-6
GAGAAGGG	2.8 (1.4-5.5)	0.002	-0.3	0.886	0.5 (0.3-1.0)	0.031
GAGCAAAG	3.3 (1.1-9.7)	0.028	-2.5	0.387	0.4 (0.1-1.4)	0.150

¹For rs-numbers see table 2. ²Data are given as OR (95% confidence interval). ³p values are calculated with logistic or linear regression models including the associated haplotypes and significantly relevant covariates in the specified windows. ⁴tag SNPs 2-6 and promoter SNPs P1-P3 in order according to chromosomal location (figure 1) with the promoter SNPs highlighted in bold.

ISSN: 1471-2350