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Table 3 The Haplotype Frequency of TLR-9 Gene Stratified by Sex among Graves' Disease Patients in Taiwan

From: Toll-like receptor gene polymorphisms are associated with susceptibility to graves' ophthalmopathy in Taiwan males

 

Haplotype 1*

 

Haplotype 2*

SNP ID

with GO

w/o GO

Pvalue†

OR‡ (95% CI)

 

with GO

w/o GO

Pvalue†

OR‡

 

N (%)

N (%)

   

N (%)

N (%)

  

Female

    

Female

    

AG

203 (68.12)

284 (63.68)

0.21

1.27 (0.92, 1.74)

GA

88 (29.53)

156 (34.98)

0.12

0.76 (0.55, 1.04)

Non-AG

95 (31.88)

162 (36.32)

 

1

Non-GA

210 (70.47)

290 (65.02)

 

1

Male

    

Male

    

AG

60 (58.82)

71 (73.96)

0.02

0.49 (0.26, 0.89)

GA

40 (39.22)

24 (25.00)

0.03

2.02 (1.09, 3.73)

Non AG

42 (41.18)

25 (26.05)

 

1

Non GA

62 (60.78)

72 (75.00)

 

1

 

P Homogeneity Test

:0.01

  

P Homogeneity Test

:0.01

 

All

         

AG

128 (32.00)

180 (33.21)

0.70

0.94 (0.71, 1.25)

GA

263 (65.75)

355 (65.50)

0.94

1.02 (0.77, 1.35)

Non AG

272 (68.00)

362 (66.79)

 

1

Non GA

137 (34.25)

187 (34.50)

 

1

  1. *Order of SNPs comprising the TLR9 haplotypes: rs187084 (A/G) and rs351401 (A/G). The haplotypes were identified by the Baysian statistical method available in the program Phase 2.1.
  2. †The chi-square test (2×2 table) was performed to obtain the p-value. P values less than 0.05 were considered significant.
  3. ‡Adjusted for diagnosis age and smoke history (ever vs. never) in unconditional logistic regression model
  4. Abbreviations: CI, confidence interval; GO, Graves' ophthalmopathy; SNP, single-nucleotide polymorphism; OR, odd ratio.
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BMC Medical Genetics

ISSN: 1471-2350

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