Table 5 GAD testing of the GeneGo network, including nicotine and the overlapping candidates

cognitive function

14

20.6

2.8E-18

1137, 6531, 6532, 1138, 1312, 1813, 57053, 1135, 2099, 627, 55584, 1139, 1141, 1142,

36.0

0.000

bipolar disorder

19

27.9

7.2E-15

1137, 6531, 1140, 1143, 8973, 6532, 1138, 1312, 1813, 1136, 57053, 1135, 1636, 627, 55584, 1134, 1139, 1141, 1142,

10.2

0.000

smoking behavior

10

14.7

1.9E-10

6531, 627, 55584, 6532, 4842, 1139, 1312, 1141, 1813, 1142,

21.9

0.000

Parkinson's disease

12

17.7

2.0E-07

1636, 1137, 6853, 2099, 6531, 627, 6532, 5743, 4842, 1312, 1813, 6571,

7.3

0.000

smoking

6

8.8

1.3E-05

1636, 6531, 7157, 6532, 1141, 1813,

18.1

0.025

methamphetamine abuse

5

7.4

2.1E-05

6531, 627, 6532, 1312, 1813,

27.3

0.042

alcoholism

7

10.3

2.2E-05

1636, 1137, 6531, 627, 6532, 1312, 1813,

11.3

0.042

Alzheimer's disease

13

19.1

5.3E-05

1137, 7157, 4842, 6532, 1312, 1136, 9632, 1636, 2099, 627, 5743, 1139, 1141,

3.8

0.104

attention deficit hyperactivity disorder

6

8.8

6.4E-05

1137, 6531, 627, 6532, 1312, 1813,

13.1

0.125

depression

6

8.8

7.2E-05

1636, 6531, 627, 6532, 1312, 1813,

12.8

0.141

depressive disorder, major

6

8.8

1.4E-04

2099, 627, 6532, 4842, 1139, 1813,

11.2

0.275

tardive dyskinesia

5

7.4

1.6E-04

6531, 6532, 4842, 1312, 1813,

16.8

0.318

personality traits

5

7.4

1.6E-04

6531, 627, 6532, 1312, 1813,

16.8

0.318

schizophrenia

13

19.1

3.3E-04

1137, 6531, 7157, 4842, 6532, 1312, 1813, 1636, 627, 5743, 1139, 1141, 6571,

3.1

0.645

mood pain

3

4.4

3.6E-04

627, 6532, 1312,

87.4

0.702

suicide

5

7.4

3.7E-04

1636, 6531, 6532, 4842, 1312,

13.7

0.729

obsessive compulsive disorder

4

5.9

5.3E-04

6531, 627, 6532, 1312,

23.3

1.027

Tourette syndrome

4

5.9

6.4E-04

6531, 6532, 1312, 1813,

21.9

1.253

eating disorders

3

4.4

7.1E-04

627, 6532, 1312,

65.6

1.390

alcoholism attention deficit hyperactivity disorder

3

4.4

7.1E-04

6532, 1312, 1813,

65.6

1.390

alcohol abuse smoking behavior

3

4.4

7.1E-04

6531, 6532, 1813,

65.6

1.390

mood disorder

4

5.9

7.7E-04

1636, 627, 6532, 1813,

20.6

1.508

heroin abuse

4

5.9

7.7E-04

6531, 6532, 1312, 1813,

20.6

1.508

anorexia nervosa

4

5.9

9.2E-04

2099, 627, 6532, 1312,

19.4

1.793

schizophrenia; tardive dyskinesia

3

4.4

1.2E-03

627, 6532, 1312,

52.5

2.290

dystonia, acute parkinsonism tardive dyskinesia

3

4.4

1.2E-03

6531, 6532, 1813,

52.5

2.290

neuroticism

3

4.4

1.2E-03

627, 6532, 1312,

52.5

2.290

obsessive-compulsive disorder

3

4.4

1.2E-03

627, 6532, 1312,

52.5

2.290

bipolar disorder schizophrenia

4

5.9

1.5E-03

627, 1139, 1312, 6571,

16.7

2.842

premenstrual dysphoric disorder

3

4.4

1.8E-03

2099, 6532, 1312,

43.7

3.393

kidney failure, chronic polycystic kidney disease

3

4.4

2.4E-03

624, 1636, 1956,

37.5

4.687