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Table 1 General characteristics of the study population with myocardial infarction (MI) and controls

From: Additive effect of LRP8/APOER2 R952Q variant to APOE ε2/ε3/ε4 genotype in modulating apolipoprotein E concentration and the risk of myocardial infarction: a case-control study

Characteristics

Controlsa

(n = 287)

MIa

(n = 394)

P

Age (years)

58.1 ± 12.6

59.9 ± 10.0

0.048 *

Male sex (%)

69.0

84.0

<0.001 #

BMI (kg/m 2 )

25.3 ± 3.4

26.6 ± 3.3

<0.001 *

Hypertension (%)

34.3

62.4

<0.001 #

Smoking (%)

44.9

70.8

<0.001 #

Diabetes (%)

6.2

16.2

<0.001 #

Total cholesterol (mmol/L)

5.54 ± 1.08

5.80 ± 1.17

0.005 *

LDL-cholesterol (mmol/L)

3.58 ± 0.95

3.94 ± 0.99

<0.001 *

HDL-cholesterol (mmol/L)

1.42 ± 0.40

1.19 ± 0.29

<0.001 *

Triglycerides (mmol/L)

1.51 ± 0.67

1.99 ± 1.09

<0.001 *

Apo A-I (g/l)

1.42 ± 0.27

1.28 ± 0.22

<0.001 *

Apo B (g/l)

1.08 ± 0.26

1.23 ± 0.31

<0.001 *

Apo C-III (mg/dl)

10.8 ± 3.2

12.2 ± 4.6

<0.001 *

ApoE (g/l)

0.043 ± 0.014

0.046 ± 0.023

0.107

LRP8 R952Q polymorphism (%)

   

   RR

43.9

38.1

 

   RQ

45.3

43.9

0.027 #

   QQ

10.8

18.0

 

APOE ε2/ε3/ε4 polymorphism (%)

   

   carrier E2

8.7

8.6

 

   E3/E3

76.7

72.1

0.280 #

   carrier E4

14.6

19.3

 
  1. a Only 681 subjects with complete analyses of LRP8 R962Q genotypes, APOE genotypes, and the ApoE plasma concentration were included.
  2. *: by t-test
  3. #: by χ2-test
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BMC Medical Genetics

ISSN: 1471-2350

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