Table 5 Genotype and case-control analyses for three GIPR SNPs
SNP | Group | genotypes, n (frequency) | frequency of allele | effect size estimate – odds ratio (95%CI)1 | p-value1 | |||
|---|---|---|---|---|---|---|---|---|
obese children and | ||||||||
rs8111428 | adolescents | 199 (0.592) AA | 124 (0.369) AG | 13 (0.039)GG | 0.777 A | 0.223 G | ORAG 1.24 (1.04;1.49) | 0.019 |
obese adults | 633 (0.642) AA | 308 (0.312) AG | 45 (0.046)GG | 0.798 A | 0.202 G | ORGG 1.54 (1.07;2.33) | ||
controls | 396 (0.676) AA | 176 (0.300) AG | 14 (0.024) GG | 0.826 A | 0.174 G | |||
obese children and | ||||||||
rs2302382 | adolescents | 176 (0.587) CC | 105 (0.350) AC | 19 (0.063) AA | 0.762 C | 0.238 A | ORAC 1.24 (1.04;1.48) | 0.014 |
obese adults | 597 (0.605) CC | 337 (0.341) AC | 53 (0.054) AA | 0.776 C | 0.224 A | ORAA 1.54 (1.09;2.19) | ||
controls | 385 (0.655) CC | 181 (0.308) AC | 22 (0.037) AA | 0.809 C | 0.191 A | |||
obese children and | ||||||||
rs1800437 | adolescents | 208 (0.619) GG | 113 (0.336) CG | 15 (0.045) CC | 0.787 G | 0.213 C | ORCG 1.11 (0.94;1.32) | 0.219 |
obese adults | 625 (0.634) GG | 319 (0.324) CG | 42 (0.043) CC | 0.796 G | 0.204 C | ORGG 1.24 (0.88;1.73) | ||
controls | 355 (0.605) GG | 200 (0.341) CC | 32 (0.055) CC | 0.775 G | 0.225 C | |||