Studies of CTNNBL1 and FDFT1variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes

Table 1 Quantitative obesity-related measures in the combined study sample

		n (men/woman)	Age (years)	BMI (kg/m²)	Body weight (kg)	Waist circumference (cm)	Height (cm)
CTNNBL1 rs6013029	GG	13,579 (7,113/6,466)	54 ± 10	27.5 ± 4.8	81.0 ± 16.2	92.5 ± 14.3	171.2 ± 9.2
	GT	1,318 (702/616)	55 ± 10	27.7 ± 4.9	82.0 ± 16.5	93.1 ± 14.5	171.8 ± 9.1
	TT	22 (9/13)	56 ± 9	27.6 ± 4.5	80.2 ± 12.5	91.9 ± 11.9	170.8 ± 7.3
	Per allele effect size (95% CI)			0.16 (-0.10–0.42)	0.89 (0.08–1.69)	0.43 (-0.26–1.12)	0.48 (0.13–0.82)
	P _add			0.2	0.03	0.2	0.007
	P _dom			0.2	0.03	0.2	0.009
CTNNBL1 rs6020846	AA	13,317 (6,972/6,345)	54 ± 10	27.5 ± 4.8	80.9 ± 16.2	92.5 ± 14.3	171.2 ± 9.2
	AG	1,527 (821/706)	55 ± 10	27.7 ± 4.9	82.1 ± 16.5	93.2 ± 14.3	171.9 ± 9.1
	GG	42 (23/19)	57 ± 9	27.8 ± 4.5	83.7 ± 15.4	94.5 ± 14.0	173.2 ± 8.4
	Per allele effect size (95% CI)			0.17 (-0.07–0.41)	1.02 (0.28–1.76)	0.54 (-0.09–1.17)	0.56 (0.25–0.88)
	P _add			0.2	0.007	0.1	5 × 10^-4
	P _dom			0.2	0.008	0.1	0.001
FDFT1 rs7001819	TT	5,929 (3,062/2,867)	55 ± 10	27.5 ± 4.9	80.8 ± 16.3	92.4 ± 14.4	171.1 ± 9.2
	TC	6,823 (3,597/3,226)	54 ± 10	28.0 ± 4.9	81.3 ± 16.4	92.4 ± 14.4	171.5 ± 9.3
	CC	1,886 (1,021/865)	55 ± 10	27.5 ± 4.8	81.0 ± 15.8	92.6 ± 13.9	171.3 ± 9.1
	Per allele effect size (95% CI)			0.01 (-0.10–0.13)	0.06 (-0.29–0.41)	0.03 (-0.28–0.33)	0.06 (-0.09–0.21)
	P _add			0.8	0.8	0.9	0.4
	P _dom			0.6	0.3	0.5	0.07

Data are means ± standard deviation. p-values were calculated assuming a additive (p _add) and a dominant (p _dom) model for all variants. Known type 2 diabetic patients were excluded from the analyses. Per allele effect sizes was calculated using linear models assuming an additive model. Adjustments were made for the effect of age and sex.

ISSN: 1471-2350