Table 1 Patients' characteristics
From: Melusin gene (ITGB1BP2) nucleotide variations study in hypertensive and cardiopathic patients
HDCOC (Naples) | DHZB (Berlin) | DHZB (Berlin) | HCG (Goettingen) | HCG (Goettingen) | |
|---|---|---|---|---|---|
Disease | chronic hypertensive patients without cardiac hypertrophic remodeling | primary hypertrophic cardiomyopathy (HCM) | primary dilated cardiomyopathy (DCM) (no hypertension). | primary DCM | severe HCM or Hypertrophic obstructive cardiomyopathy (HOCM) |
# of patients analyzed | 285 | 106 | 85 | 139 | 40 |
Age (year) | 60.3 ± 0.8 | (at echo) 53 ± 1.35 | (at echo) 50 ± 1.0 | (at echo) 58.2 ± 14.0 | (at echo) 56.8 ± 21.2 |
Sex M/F (%) | 66.1/33.9 | 61/39 | 77.6/22.4 | 80/20 | 62.5/37.5 |
BMI Kg/m2 | 27.6 ± 0.3 | 27.3 ± 0.42 | 26.3 ± 0.41 | 28 ± 5.5 | 27.9 ± 5.9 |
LVEDD (mm) | 50.9 ± 0.3 | 46.0 ± 0.73 | 69.9 ± 1.0 | 63.5 ± 8.1 | 53.2 ± 6.7 |
LVEF (%) | n.a. | n.a. | 24.8 ± 0.66 | 30.2 ± 9.9 | 49.4 ± 12.9 |
IVS (mm) | 10.9 ± 0.11 | 18.1 ± 0.47 | n.a. | 10.6 ± 1.8 | 14.6 ± 3.7 |
PW (mm) | 9.4 ± 0.07 | n.a. | n.a. | n.a. | n.a. |
FS (%) | 34.9 ± 0.3 | 33.7 ± 1.04 | n.a. | n.a. | n.a. |
SBP (mmHg) | 160.7 ± 1.4 | n.a. | n.a. | n.a. | n.a. |
DBP (mmHg) | 100.7 ± 1.0 | n.a. | n.a. | n.a. | n.a. |
Benign hypertension (%) | n.a. | 37 | n.a. | 21.5 | 7.5 |
Diabetes melliyus (%) | 6 | 7.6 | n.a. | 7.15 | 2.5 |
Hyperlipoproteinaemia (%) | 37.7 | 32 | n.a. | n.a. | n.a. |
Smoking history (%) | 26.2 | 47 | n.a. | n.a. | n.a. |
Positive family history (%) | 82 (Hypertension) | 45 (HCM) | 18 (DCM) | 20 (DCM) | 27.5 (HCM or HOCM) |