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Table 2 Allele frequency distribution of HLA-DRB1* in patients versus controls, and MB versus PB forms of leprosy

From: Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population

  Patients Controls    MB PB  
  (n= 305) (n= 527)    (n = 179) (n = 126)  
Alleles 2 n AF 2 n AF P -value Pc -value AF AF P -value
HLA-DRB1*01 19 0.03 23 0.02 0.246   0.02 0.04 0.136
HLA-DRB1*03 14 0.02 40 0.04 0.520   0.04 0.02 0.224
HLA-DRB1*04 44 0.07 98 0.09 0.387   0.09 0.09 0.471
HLA-DRB1*07 73 0.12 164 0.16 0.427   0.16 0.13 0.197
HLA-DRB1*08 30 0.05 53 0.05 0.965   0.05 0.04 0.497
HLA-DRB1*09 49 0.08 140 0.13 0.002 0.026 0.13 0.07 0.06
HLA-DRB1*10 5 0.01 13 0.01 0.564   0.01 0.00 0.571
HLA-DRB1*11 43 0.07 76 0.07 0.585   0.07 0.06 0.188
HLA-DRB1*12 61 0.10 114 0.11 0.879   0.11 0.12 0.705
HLA-DRB1*13 29 0.05 63 0.06 0.058   0.06 0.04 0.232
HLA-DRB1*14 31 0.05 52 0.05 0.522   0.05 0.06 0.183
HLA-DRB1*15 195 0.32 185 0.18 < 0.001 < 0.001 0.18 0.29 0.991
HLA-DRB1*16 17 0.03 33 0.03 0.844   0.03 0.03 0.838
  1. n, number of individuals; AF, allelic frequency.
  2. P-values are from allele-based tests.