Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population

Table 2 Allele frequency distribution of HLA-DRB1* in patients versus controls, and MB versus PB forms of leprosy

	Patients		Controls				MB	PB
	(n= 305)		(n= 527)				(n = 179)	(n = 126)
Alleles	2 n	AF	2 n	AF	P -value	Pc -value	AF	AF	P -value
HLA-DRB101*	19	0.03	23	0.02	0.246		0.02	0.04	0.136
HLA-DRB103*	14	0.02	40	0.04	0.520		0.04	0.02	0.224
HLA-DRB104*	44	0.07	98	0.09	0.387		0.09	0.09	0.471
HLA-DRB107*	73	0.12	164	0.16	0.427		0.16	0.13	0.197
HLA-DRB108*	30	0.05	53	0.05	0.965		0.05	0.04	0.497
**HLA-DRB109***	49	0.08	140	0.13	0.002	0.026	0.13	0.07	0.06
HLA-DRB110*	5	0.01	13	0.01	0.564		0.01	0.00	0.571
HLA-DRB111*	43	0.07	76	0.07	0.585		0.07	0.06	0.188
HLA-DRB112*	61	0.10	114	0.11	0.879		0.11	0.12	0.705
HLA-DRB113*	29	0.05	63	0.06	0.058		0.06	0.04	0.232
HLA-DRB114*	31	0.05	52	0.05	0.522		0.05	0.06	0.183
**HLA-DRB115***	195	0.32	185	0.18	< 0.001	< 0.001	0.18	0.29	0.991
HLA-DRB116*	17	0.03	33	0.03	0.844		0.03	0.03	0.838

ISSN: 1471-2350