Skip to main content

Advertisement

Table 3 Genotype and allele distributions in patients with essential hypertension and in control individuals

From: Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study

   Total Male Female
SNPs Genotype Case (n = 383) Control (n = 500) P Case (n = 171) Control (n = 204) P Case (n = 212) Control (n = 296) P
rs2288774 n(%)           
Additive model T/T 123 (32.5) 177 (35.8) 0.365 60 (35.7) 71 (35.1) 0.661 63 (30.0) 106 (36.2) 0.296
  C/T 173 (45.8) 228 (46.1)   76 (45.2) 99 (49.0)   97 (46.2) 129 (44.0)  
  C/C 82 (21.7) 90 (18.1)   32 (19.1) 32 (15.9)   50 (23.8) 58 (19.8)  
Dominant model T/T 123 (32.5) 177 (35.8) 0.984 60 (35.7) 71 (35.1) 0.909 63 (30.0) 106 (36.2) 0.148
  T/C+C/C 255 (67.5) 318 (64.2)   108 (64.3) 131 (64.9)   147 (70.0) 187 (63.8)  
Recessive model T/T+C/T 296 (78.3) 405 (81.9) 0.192 136 (80.9) 170 (84.1) 0.417 160 (76.2) 235 (80.2) 0.279
  C/C 82 (21.7) 90 (18.1)   32 (19.1) 32 (15.9)   50 (23.8) 58 (19.8)  
Allele T 419 (55.4) 582 (58.8) 0.159 196 (58.3) 241 (59.7) 0.716 223 (53.1) 341 (58.2) 0.108
  C 337 (44.6) 409 (41.2)   140 (41.7) 163 (40.3)   197 (46.9) 245 (41.8)  
rs2288775 n(%)           
Additive model A/A 210 (55.0) 302 (60.9) 0.189 100 (58.8) 122 (60.7) 0.901 110 (51.9) 180 (61.0) 0.114
  A/G 146 (38.2) 168 (33.9)   61 (35.9) 70 (34.8)   85 (40.1) 98 (33.2)  
  G/G 26 (6.8) 26 (5.2)   9 (5.3) 9 (4.5)   17 (8.0) 17 (5.8)  
Dominant model A/A 210 (55.0) 302 (60.9) 0.078 100 (58.8) 122 (60.7) 0.714 110 (51.9) 180 (61.0) 0.040*
  A/G+G/G 172 (45.0) 194 (39.1)   70 (41.2) 79 (39.3)   102 (48.1) 115 (39.0)  
Recessive model A/A+AG 356 (93.2) 470 (94.8) 0.948 161 (94.7) 192 (95.5) 0.715 195 (92.0) 278 (94.2) 0.316
  G/G 26 (6.8) 26 (5.2)   9 (5.3) 9 (4.5)   17 (8.0) 17 (5.8)  
Allele A 566 (74.1) 772 (77.8) 0.065 261 (76.8) 314 (78.1) 0.662 305 (71.9) 458 (77.6) 0.038*
  G 198 (25.9) 220 (22.2)   79 (23.2) 88 (21.9)   119 (28.1) 132 (22.4)  
296921-296923 delTTG n(%)           
Additive model I/I 186 (48.8) 258 (52.3) 0.217 91 (53.5) 111 (54.7) 0.674 95 (45.0) 147 (50.7) 0.024*
  I/D 155 (40.7) 199 (40.4)   69 (40.6) 76 (37.4)   86 (40.8) 123 (42.4)  
  D/D 40 (10.5) 36 (7.3)   10 (5.9) 16 (7.9)   30 (14.2) 20 (6.9)  
Dominant model I/I 186 (48.8) 258 (52.3) 0.303 91 (53.5) 111 (54.7) 0.824 95 (45.0) 147 (50.7) 0.210
  D/D+I/D 195 (51.2) 235 (47.7)   79 (46.5) 92 (45.3)   116 (55.0) 143 (49.3)  
Recessive model I/I+I/D 341 (89.5) 457 (92.7) 0.096 160 (94.1) 187 (92.1) 0.450 181 (85.8) 270 (93.1) 0.007*
  D/D 40 (10.5) 36 (7.3)   10 (5.9) 16 (7.9)   30 (14.2) 20 (6.9)  
Allele I 527 (69.2) 715 (72.5) 0.125 251 (73.8) 298 (73.4) 0.896 276 (65.4) 417 (71.9) 0.028*
  D 235 (30.8) 271 (27.5)   89 (26.2) 108 (26.6)   146 (34.6) 163 (28.1)  
  1. * P < 0.05