Table 3 Genotype and allele distributions in patients with essential hypertension and in control individuals
| Â | Â | Total | Male | Female | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
SNPs | Genotype | Case (n = 383) | Control (n = 500) | P | Case (n = 171) | Control (n = 204) | P | Case (n = 212) | Control (n = 296) | P |
rs2288774 n(%) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Additive model | T/T | 123 (32.5) | 177 (35.8) | 0.365 | 60 (35.7) | 71 (35.1) | 0.661 | 63 (30.0) | 106 (36.2) | 0.296 |
| Â | C/T | 173 (45.8) | 228 (46.1) | Â | 76 (45.2) | 99 (49.0) | Â | 97 (46.2) | 129 (44.0) | Â |
| Â | C/C | 82 (21.7) | 90 (18.1) | Â | 32 (19.1) | 32 (15.9) | Â | 50 (23.8) | 58 (19.8) | Â |
Dominant model | T/T | 123 (32.5) | 177 (35.8) | 0.984 | 60 (35.7) | 71 (35.1) | 0.909 | 63 (30.0) | 106 (36.2) | 0.148 |
| Â | T/C+C/C | 255 (67.5) | 318 (64.2) | Â | 108 (64.3) | 131 (64.9) | Â | 147 (70.0) | 187 (63.8) | Â |
Recessive model | T/T+C/T | 296 (78.3) | 405 (81.9) | 0.192 | 136 (80.9) | 170 (84.1) | 0.417 | 160 (76.2) | 235 (80.2) | 0.279 |
| Â | C/C | 82 (21.7) | 90 (18.1) | Â | 32 (19.1) | 32 (15.9) | Â | 50 (23.8) | 58 (19.8) | Â |
Allele | T | 419 (55.4) | 582 (58.8) | 0.159 | 196 (58.3) | 241 (59.7) | 0.716 | 223 (53.1) | 341 (58.2) | 0.108 |
| Â | C | 337 (44.6) | 409 (41.2) | Â | 140 (41.7) | 163 (40.3) | Â | 197 (46.9) | 245 (41.8) | Â |
rs2288775 n(%) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Additive model | A/A | 210 (55.0) | 302 (60.9) | 0.189 | 100 (58.8) | 122 (60.7) | 0.901 | 110 (51.9) | 180 (61.0) | 0.114 |
| Â | A/G | 146 (38.2) | 168 (33.9) | Â | 61 (35.9) | 70 (34.8) | Â | 85 (40.1) | 98 (33.2) | Â |
| Â | G/G | 26 (6.8) | 26 (5.2) | Â | 9 (5.3) | 9 (4.5) | Â | 17 (8.0) | 17 (5.8) | Â |
Dominant model | A/A | 210 (55.0) | 302 (60.9) | 0.078 | 100 (58.8) | 122 (60.7) | 0.714 | 110 (51.9) | 180 (61.0) | 0.040* |
| Â | A/G+G/G | 172 (45.0) | 194 (39.1) | Â | 70 (41.2) | 79 (39.3) | Â | 102 (48.1) | 115 (39.0) | Â |
Recessive model | A/A+AG | 356 (93.2) | 470 (94.8) | 0.948 | 161 (94.7) | 192 (95.5) | 0.715 | 195 (92.0) | 278 (94.2) | 0.316 |
| Â | G/G | 26 (6.8) | 26 (5.2) | Â | 9 (5.3) | 9 (4.5) | Â | 17 (8.0) | 17 (5.8) | Â |
Allele | A | 566 (74.1) | 772 (77.8) | 0.065 | 261 (76.8) | 314 (78.1) | 0.662 | 305 (71.9) | 458 (77.6) | 0.038* |
| Â | G | 198 (25.9) | 220 (22.2) | Â | 79 (23.2) | 88 (21.9) | Â | 119 (28.1) | 132 (22.4) | Â |
296921-296923 delTTG n(%) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Additive model | I/I | 186 (48.8) | 258 (52.3) | 0.217 | 91 (53.5) | 111 (54.7) | 0.674 | 95 (45.0) | 147 (50.7) | 0.024* |
| Â | I/D | 155 (40.7) | 199 (40.4) | Â | 69 (40.6) | 76 (37.4) | Â | 86 (40.8) | 123 (42.4) | Â |
| Â | D/D | 40 (10.5) | 36 (7.3) | Â | 10 (5.9) | 16 (7.9) | Â | 30 (14.2) | 20 (6.9) | Â |
Dominant model | I/I | 186 (48.8) | 258 (52.3) | 0.303 | 91 (53.5) | 111 (54.7) | 0.824 | 95 (45.0) | 147 (50.7) | 0.210 |
| Â | D/D+I/D | 195 (51.2) | 235 (47.7) | Â | 79 (46.5) | 92 (45.3) | Â | 116 (55.0) | 143 (49.3) | Â |
Recessive model | I/I+I/D | 341 (89.5) | 457 (92.7) | 0.096 | 160 (94.1) | 187 (92.1) | 0.450 | 181 (85.8) | 270 (93.1) | 0.007* |
| Â | D/D | 40 (10.5) | 36 (7.3) | Â | 10 (5.9) | 16 (7.9) | Â | 30 (14.2) | 20 (6.9) | Â |
Allele | I | 527 (69.2) | 715 (72.5) | 0.125 | 251 (73.8) | 298 (73.4) | 0.896 | 276 (65.4) | 417 (71.9) | 0.028* |
| Â | D | 235 (30.8) | 271 (27.5) | Â | 89 (26.2) | 108 (26.6) | Â | 146 (34.6) | 163 (28.1) | Â |