Fig. 3

Effect of western diet on growth parameters and body composition in mice lacking Stap1 gene. Panel a shows the growth curves in wild-type and knockout mice and no statistical differences were discernable in the patterns of weight gain on the high caloric diet (n = 6). Neither the percent fat or lean mass were altered in Stap1^−/− mice compared to age and sex-matched wildtype mice on a western diet (panel b, n = 6). No changes in weights of liver, spleen or kidneys were seen in male (panel c, n = 4–6) or female mice (panel d, n = 5–6) were noted. No changes in glucose tolerance tests were noted between knockout and wildtype controls either (panel e, n = 6). In case of male Stap1^−/− mice, kidney weights of only 2 mice were considered for analysis