Incidence of Huntington disease in a northeastern Spanish region: a 13-year retrospective study at tertiary care centre

Table 3 Cases with CAG repeats in the intermediate range (27–35) and their relatives with other CAG repeats

Patient	Sex	CAG repeats		Family history	Clinical manifestations
Patient	Sex	A1	A2	Family history	Clinical manifestations
1	Male	17	29	HD confirmed two siblings	–
Relatives	Male	19	44	Brother	Depression
	Female	17	44	Sister	Essential tremor, bradykinesia, stiffness in the upper right limb
	Female	17	19	Sister	–
2^a	Male	16	43	Negative	Generalized dystonia, multiple motor tics
Relatives	Male	19	33	Father	–
Relatives	Female	17	33	Sister	–
	Male	17	33	Brother	–
3	Female	18	27	Negative	Generalized choreic movements, muscle contractions
4	Female	17	31	HD suspected father and paternal aunts	Depression, anxiety, phobia, chronic stress
5	Male	18	34	Negative	Progressive instability, choreic movements and restlessness

Distribution of cases by genetic results of intermediate allele and family history in predictive and diagnostic test performed. A1 allele, A2 allele 2. ^aIn this case, the proband (patient 2) presented an allele in the full penetrance range, being his relatives the carriers of the intermediate allele

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