Mediation by differential DNA methylation of known associations between single nucleotide polymorphisms and bladder cancer risk

Table 3 Mediating effects of mQTL-associated CpG site(s) for association between each SNP and bladder cancer risk

SNP	Region	Gene	RA	Mediator(s)	Effect of SNP^a	OR	95% CI
rs798766	4p16.3	TMEM129-TACC3-FGFR3	T	cg00006948	NDE	1.16	(0.86, 1.50)
					NIE	0.95	(0.81, 1.08)
					TE	1.10	(0.85, 1.38)
rs401681	5p15.33	TERT-CLPTML	C	cg27028750 cg26209169	NDE	1.01	(0.76, 1.33)
					NIE	1.05	(0.89, 1.25)
					TE	1.05	(0.85, 1.30)
rs2294008	8q24.3	PSCA	T	cg06565975 cg03405983 cg24023258 cg17888033 cg17252645	NDE	1.04	(0.78, 1.35)
					NIE	1.10	(0.90, 1.33)
					TE	1.13	(0.91, 1.38)
rs8102137	19q12	CCNE1	C	cg16836589 cg27475126	NDE	1.36	(1.05, 1.74)
					NIE	1.02	(0.93, 1.11)
					TE	1.38	(1.09, 1.74)

^aMediation models were adjusted for race/ethnicity, smoking status, pack-years of smoking, WHI arm, age at baseline, year of enrollment, follow-up time, and DNA extraction method
Abbreviations: RA Risk allele; CI Confidence interval; NDE Natural direct effect; NIE Natural indirect effect; TE Total effect

ISSN: 1471-2350