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Fig. 4 | BMC Medical Genetics

Fig. 4

From: Characterization of an N-terminal Nav1.5 channel variant – a potential risk factor for arrhythmias and sudden death?

Fig. 4

S106G mutation does not affect unitary channel conductance. a Exemplary recordings of a HEK293 cell expressing the Nav1.5 WT channel for noise analysis. Channels were activated 200 times by stepping membrane from holding voltage (1–40 mV, 100 ms) to test voltage of − 20 mV (100 ms). Red arrows delimit the part of the traces used for the analysis. b Example of noise analysis from one cell expressing Nav1.5 WT channel. The variance between pulses is plotted as a function of the mean current value. The data were fitted with parabolic function (Eq. 5) yielding the unitary channel conductance from the initial slope of the fit. c Average i values (mean ± SE) for WT and S106G channels at two different voltages: − 20 mV (WT n = 3, black; S106G n = 4, red) and − 40 mV (WT n = 4, black; S106G n = 4, red)

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