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Table 2 Associations of the Top 20 SNPS with Prevalent Cervical high-risk Infections

From: Genome-wide association study of prevalent and persistent cervical high-risk human papillomavirus (HPV) infection

SNP

Chr

Base Position

Near gene

Reference allele

MAF

OR

95% CI

P-value

rs149473200

13

74,295,767

KLF12

G

0.03

7.06

3.19–15.63

1.43 × 10− 6

rs147344426

13

74,298,464

KLF12

G

0.03

7.06

3.19–15.63

1.43 × 10− 6

rs151071053

13

74,299,405

KLF12

T

0.03

7.06

3.19–15.63

1.43 × 10− 6

rs572823632

13

74,299,732

KLF12a

GAA

0.03

7.06

3.19–15.63

1.43 × 10− 6

rs73010973

4

181,310,690

NCRNA00290

T

0.06

3.86

2.22–6.72

1.70 × 10− 6

rs73010975

4

181,310,704

NCRNA00290

T

0.06

3.86

2.22–6.72

1.70 × 10− 6

rs74739185

4

181,311,019

NCRNA00290

G

0.06

3.86

2.22–6.72

1.70 × 10− 6

rs79140020

4

181,311,020

NCRNA00290

T

0.06

3.86

2.22–6.72

1.70 × 10− 6

rs35833676

21

32,961,256

TIAM1

C

0.07

3.45

2.07–5.73

1.79 × 10− 6

rs3818252

20

58,675,675

C20orf197

C

0.57

2.22

1.60–3.10

2.06 × 10− 6

rs112893815

4

181,311,254

NCRNA00290

C

0.06

3.77

2.17–6.53

2.22 × 10− 6

–

8

74,725,256

UBE2Wa

G

–

3.31

2.01–5.44

2.42 × 10− 6

rs506594

11

64,162,897

RPS6KA4

T

0.77

0.44

0.31–0.62

2.67 × 10− 6

rs73010952

4

181,308,382

NCRNA00290

G

0.06

3.69

2.14–6.38

2.77 × 10− 6

rs111800742

4

181,308,587

NCRNA00290

C

0.06

3.69

2.14–6.38

2.77 × 10− 6

rs73010957

4

181,309,080

NCRNA00290

A

0.06

3.69

2.14–6.38

2.77 × 10− 6

rs6574170

14

74,729,207

VSX2

A

0.04

5.29

2.63–10.67

3.16 × 10− 6

–

17

36,374,963

LOC440434a

TA

–

0.48

0.35–0.65

3.17 × 10− 6

rs17090215

13

74,039,057

KLF12

C

0.05

3.90

2.20–6.92

3.21 × 10−6

rs375435036

1

72,615,562

NEGR1a

C

0.15

2.52

1.71–3.73

3.49 × 10− 6

  1. For this analysis, 125 women with cervical hrHPV infections were compared to 392 women without cervical hrHPV infections at baseline. Base positions were based on hg19; aThe variant is not in 1000 genomes v1, the nearest gene was obtained from variants surrounding the base location on the specific chromosome; Odds Ratio (OR) and 95% Confidence Intervals (CI) were estimated using an additive genetic model; Models were adjusted for age, HIV status and the first principal components of the genotypes