Table 2 Summary ORs (95% CI) of UGT1A1 (c.-3279 T > G) gene polymorphisms and neonatal hyperbilirubinemia risk
From: The role of UGT1A1 (c.-3279 T > G) gene polymorphisms in neonatal hyperbilirubinemia susceptibility
Genetic model | Subgroup analysis | No. of studies | OR (95% CI) | P | I2% | P (Q test) | Egger’s test | Begg’s test |
|---|---|---|---|---|---|---|---|---|
G vs T | Total | 7 | 1.288 (0.982–1.689) | 0.067 | 63.9 | 0.011 | 0.766 | 1.000 |
Asian | 5 | 1.334 (0.939–1.896) | 0.108 | 66.3 | 0.018 | |||
African | 1 | 1.669 (0.907–3.072) | 0.100 | 0 | 1.000 | |||
Caucasian | 1 | 0.978 (0.742–1.289) | 0.874 | 0 | 1.000 | |||
GG vs TT | Total | 7 | 1.865 (1.031–3.373) | 0.039 | 67.5 | 0.005 | 0.203 | 0.368 |
Asian | 5 | 1.958 (0.946–4.052) | 0.070 | 67.3 | 0.016 | |||
African | 1 | 5.625 (1.177–26.877) | 0.030 | 0 | 1.000 | |||
Caucasian | 1 | 0.974 (0.564–1.682) | 0.925 | 0 | 1.000 | |||
GG vs GT | Total | 7 | 1.557 (0.883–2.745) | 0.126 | 71.3 | 0.002 | 0.057 | 0.072 |
Asian | 7 | 1.365 (0.806–2.314) | 0.247 | 51.5 | 0.083 | |||
African | 1 | 16.364 (3.188–83.993) | 0.001 | 0 | 1.000 | |||
Caucasian | 1 | 0.808 (0.508–1.284) | 0.367 | 0 | 1.000 | |||
GT vs TT | Total | 7 | 1.100 (0.720–1.681) | 0.660 | 58.6 | 0.024 | 0.331 | 0.368 |
Asian | 5 | 1.322 (0.849–2.057) | 0.216 | 43.3 | 0.133 | |||
African | 1 | 0.344 (0.133–0.886) | 0.027 | 0 | 1.000 | |||
Caucasian | 1 | 1.206 (0.739–1.968) | 0.454 | 0 | 1.000 | |||
GT + GG vs TT | Total | 7 | 1.331 (1.055–1.679) | 0.016 | 49.1 | 0.067 | 0.603 | 0.764 |
Asian | 5 | 1.427 (0.875–2.326) | 0.154 | 58 | 0.049 | |||
African | 1 | 0.872 (0.389–1.952) | 0.739 | 0 | 1.000 | |||
Caucasian | 1 | 1.114 (0.703–1.764) | 0.646 | 0 | 1.000 | |||
GG vs TT + GT | Total | 7 | 1.583 (0.947–2.647) | 0.080 | 69.5 | 0.003 | 0.084 | 0.072 |
Asian | 5 | 1.549 (0.894–2.685) | 0.119 | 60.1 | 0.040 | |||
African | 1 | 8.372 (1.832–38.260) | 0.006 | 0 | 1.000 | |||
Caucasian | 1 | 0.860 (0.556–1.329) | 0.496 | 0 | 1.000 | |||
GT vs TT + GG | Total | 7 | 0.903 (0.631–1.293) | 0.578 | 59.2 | 0.023 | 0.061 | 0.133 |
Asian | 5 | 1.062 (0.821–1.374) | 0.648 | 0 | 0.434 | |||
African | 1 | 0.235 (0.095–0.584) | 0.002 | 0 | 1.000 | |||
Caucasian | 1 | 1.223 (0.828–1.808) | 0.312 | 0 | 1.000 |