From: Effect of DNMT3A polymorphisms on CpG island hypermethylation in gastric mucosa
number of methylated gene | 0 | 1 | 2 | 3 | 4 |
---|---|---|---|---|---|
number of sample | 123 | 156 | 131 | 75 | 25 |
mean age ± SD | 59.8 ± 14.9 | 59.9 ± 13.3 | 59.5 ± 14.1 | 61.9 ± 12.3 | 68.2 ± 10.3a |
male: female | 66: 57 | 100: 56 | 71: 60 | 46: 29 | 14: 11 |
HP infection status | 53/123 | 89/156b | 89/131c | 67/75c | 23/25c |
(rs6733868 C > G) | |||||
 CC | 36 | 56 | 61d | 44c | 15e |
 CG | 57 | 82 | 53 | 24 | 8 |
 GG | 30 | 18f | 17g | 7h | 2 |
 G allele freuqency | 47.6% | 37.8%i | 33.2%j | 25.3%c | 24.0%k |
(rs13428812 A > G) | |||||
 AA | 57 | 93l | 82m | 61c | 20n |
 AG | 53 | 57 | 43 | 10 | 3 |
 GG | 13 | 6o | 6 | 4 | 2 |
 G allele frequency | 32.1% | 22.1%p | 21.0%q | 12.0%c | 14.0%r |