Effect of DNMT3A polymorphisms on CpG island hypermethylation in gastric mucosa

BMC Medical Genetics

Table 2 Characteristics of the subjects and allelic frequency in CpG methylated population of each genes

	overall	p14^ARF-M	p16^INK4a-M	DAPK-M	CDH1-M
number of sample	510	167	134	252	192
mean age ± SD	60.5 ± 13.7	62.9 ± 13.7^a	61.2 ± 11.8	61.5 ± 13.6	60.3 ± 13.0
male: female	297: 213	91: 76	78: 56	150: 102	117: 75
HP infection status	321/510	117/167^b	111/134^c	186/252^c	148/192^c
(rs6733868 C > G)
CC	212	81^d	69^e	122^f	100^g
CG	224	61	49	112^c	70
GG	74	25	16	18	22
G allele freqency	36.5%	33.2%	30.2%^h	29.4%^c	29.7%ⁱ
(rs13428812 A > G)
AA	313	111	97^j	169^k	145^c
AG	166	47	28	73	37
GG	31	9	9	10	10
G allele freqency	22.4%	19.5%	17.2%^l	18.5%^m	14.8%^c

-M Methylated
a: p = 0.0046, b: p = 0.019, c: p < 0.0001, d: p = 0.028, e: p = 0.0079, f: p = 0.0022, g: p = 0.0002, h: p = 0.015, i: p = 0.0005,
j: p = 0.0027, k: p = 0.011, l: p = 0.017, m: p = 0.0034 vs. unmathylated group of each gene

ISSN: 1471-2350