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Table 3 Association of PIP5K2A haplotypes with course of schizophrenia

From: Genetic polymorphisms of PIP5K2A and course of schizophrenia

SNPs Haplotype Frequency Group 1, Group 2 frequencies Chi square Pasym PPerm
rs736203/rs943190 TT 0.571 0.565, 0.585 0.269 0.6043 0.9971
CC 0.342 0.332, 0.366 0.836 0.3606 0.9437
TC 0.046 0.053, 0.031 1.715 0.1904 0.7448
CT 0.040 0.050, 0.018 4.463 0.0346 0.2097
rs10430590/rs1132816 AA 0.570 0.557, 0.608 1.397 0.2372 0.5328
TA 0.211 0.211, 0.212 0.001 0.9750 1.0
AG 0.127 0.128, 0.126 0.005 0.9451 0.9998
TG 0.091 0.104, 0.054 3.990 0.0458 0.1130
rs943190/rs1132816 TA 0.497 0.501, 0.487 0.108 0.7430 0.9812
CA 0.285 0.268, 0.334 2.827 0.0927 0.2276
TG 0.117 0.117, 0.119 0.008 0.9309 0.9998
CG 0.101 0.115, 0.061 4.276 0.0386 0.0946
rs11013052/rs1132816 CA 0.643 0.632, 0.675 1.075 0.2998 0.6804
AA 0.139 0.137, 0.145 0.079 0.7791 0.9898
AG 0.114 0.129, 0.073 4.119 0.0424 0.1423
CG 0.104 0.103, 0.107 0.029 0.8652 0.9973
rs1132816/rs943194 AG 0.606 0.595, 0.637 1.004 0.3163 0.9144
AC 0.175 0.173, 0.183 0.099 0.7535 0.9998
GC 0.175 0.175, 0.103 5.158 0.0231 0.1419
GG 0.063 0.058, 0.077 0.786 0.3754 0.9502
  1. Pasym - asymptotic P value, PPerm - empirical P value for 10,000 permutations. Group 1 – group of patients with continuous course of schizophrenia (n = 269), Group 2 – group of patients with episodic course of schizophrenia (n = 115). Bold text indicates p-value< 0.05