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Fig. 3 | BMC Medical Genetics

Fig. 3

From: Unannotated single nucleotide polymorphisms in the TATA box of erythropoiesis genes show in vitro positive involvements in cognitive and mental disorders

Fig. 3

The significant correlations between the in silico predicted and in vitro experimentally measured values. Legend: a TBP–DNA affinity and b the TBP–DNA affinity change caused by the minor allele of the analyzed SNPs with respect to the norm, −ln [KD] and Δln [KD], respectively. Solid and dashed lines denote the linear regression and boundaries of its 95% confidence interval, calculated by means of software package STATISTICA (Statsoft™, USA); arrows pinpoint the ancestral rs34500389:C and minor rs34500389:t alleles of the SNP being studied, an analysis of which is depicted in Fig. 1 as an example of the application of our Web service SNP_TATA_Z-tester [31] in this work; r, τ, γ, and p are coefficients of Pearson’s linear correlation, Spearman’s rank correlation, Kendall’s rank correlation, and Goodman–Kruskal generalized correlation and their p values, respectively

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