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Table 4 Clinical and metabolic characteristics of genotypes containing rs2479106, rs2768819, rs2670139, rs2536951 and rs2479102 in PCOS cases and controls

From: Association analysis between the tag single nucleotide polymorphisms of DENND1A and the risk of polycystic ovary syndrome in Chinese Han women

Genotypes

Control

p-value

PCOS

p-value

rs2479106

AG

AA

GG

AG

AA

GG

Age (years)

33.53 ± 0.65

32.58 ± 0.49

34.40 ± 2.27

0.771

26.97 ± 0.72

26.15 ± 0.60

33.00 ± 0.49

0.227

BMI (kg/m2)

22.72 ± 0.49

21.51 ± 0.26

23.41 ± 0.62

0.143

23.33 ± 0.72

23.06 ± 0.54

19.96 ± 0.49

0.268

E2(pg/ml)

63.06 ± 7.36

57.13 ± 4.40

42.87 ± 5.23

0.436

209.61 ± 25.42

256.54 ± 16.61

102.19 ± 28.39

0.184

T(nm/l)

2.93 ± 0.17

2.04 ± 0.32

1.34 ± 0.32

0.147

3.99 ± 1.06

6.27 ± 2.15

2.84 ± 1.05

0.727

E2/T(ln)

21.33 ± 1.72

72.21 ± 25.10

33.11 ± 2.87

0.335

92.12 ± 12.49

93.92 ± 12.68

35.98 ± 5.49

0.797

LH(IU/l)

5.94 ± 0.64

4.79 ± 0.29

2.56 ± 0.83

0.013*

15.73 ± 1.31

17.11 ± 1.19

9.79 ± 1.48

0.318

FSH(IU/l)

8.40 ± 0.66

7.90 ± 0.31

7.00 ± 0.41

0.701

7.17 ± 0.50

6.27 ± 0.33

6.78 ± 0.29

0.551

LH/FSH

0.78 ± 0.07

0.64 ± 0.04

0.36 ± 0.11

0.007*

2.99 ± 0.19

2.94 ± 0.20

1.44 ± 0.12

0.068

PRL(μg/l)

4.67 ± 1.35

6.31 ± 1.78

1.79 ± 0.03

0.724

14.62 ± 1.59

18.21 ± 2.10

5.75 ± 1.05

0.365

rs2768819

Control

p-value

PCOS

p-value

AG

AA

GG

 

AG

AA

GG

Age (years)

32.6 ± 0.77

33.58 ± 0.51

34.00 ± 1.00

0.935

28.63 ± 0.84

27.24 ± 0.80

22.5 ± 0.65

0.269

BMI (kg/m2)

22.7 ± 0.59

21.93 ± 0.32

21.69 ± 2.79

0.465

13.52 ± 0.88

23.30 ± 0.79

19.72 ± 0.86

0.678

E2(pg/ml)

62.7 ± 8.65

61.36 ± 5.27

56.36 ± 25.64

0.983

197.51 ± 32.63

192.59 ± 17.67

250.90 ± 30.35

0.899

T(nm/l)

2.71 ± 0.33

2.09 ± 0.14

1.67 ± 0.65

0.339

2.01 ± 0.15

2.55 ± 0.26

3.35 ± 0.64

0.225

E2/T(ln)

20.5 ± 3.37

72.51 ± 10.75

32.75 ± 2.51

0.241

109.08 ± 16.66

75.45 ± 15.55

84.77 ± 17.94

0.917

LH(IU/l)

5.45 ± 0.52

5.19 ± 0.34

4.58 ± 1.41

0.905

11.75 ± 1.26

16.66 ± 1.61

31.70 ± 2.34

0.013*

FSH(IU/l)

6.59 ± 0.28

8.04 ± 0.38

8.42 ± 0.44

0.057

6.58 ± 0.54

7.06 ± 0.50

6.21 ± 0.54

0.779

LH/FSH

0.89 ± 0.09

0.68 ± 0.04

0.54 ± 0.14

0.222

1.85 ± 0.16

2.44 ± 0.21

5.26 ± 0.69

0.002*

PRL(μg/l)

4.58 ± 2.91

7.64 ± 2.18

1.80 ± 0.06

0.583

15.16 ± 1.69

19.53 ± 3.71

24.43 ± 1.33

0.618

rs2536951

Control

p-value

PCOS

p-value

AG

AA

GG

AG

AA

GG

Age (years)

33.3 ± 0.99

32.61 ± 0.52

32.30 ± 0.96

0.667

27.43 ± 0.68

25.98 ± 0.62

30.00 ± 2.00

0.166

BMI (kg/m2)

22.3 ± 0.61

21.71 ± 0.31

21.44 ± 0.80

0.442

23.41 ± 0.79

22.99 ± 0.58

26.89 ± 3.16

0.413

E2(pg/ml)

61.0 ± 6.03

56.40 ± 4.51

59.45 ± 12.17

0.861

217.63 ± 29.31

247.00 ± 19.28

232.68 ± 80.20

0.699

T(nm/l)

2.85 ± 0.37

2.28 ± 0.36

1.09 ± 0.07

0.268

3.43 ± 0.83

4.01 ± 0.48

2.12 ± 0.56

0.67

E2/T(ln)

20.7 ± 9.80

70.70 ± 27.74

28.84 ± 1.41

0.412

93.06 ± 14.93

89.39 ± 12.39

107.24 ± 9.50

0.947

LH(IU/l)

6.19 ± 0.51

5.07 ± 0.38

5.25 ± 0.70

0.284

15.74 ± 1.47

17.21 ± 1.37

12.58 ± 2.02

0.739

FSH(IU/l)

8.10 ± 0.59

8.14 ± 0.37

7.70 ± 0.79

0.93

6.77 ± 0.51

6.36 ± 0.38

7.36 ± 0.71

0.65

LH/FSH

0.88 ± 0.07

0.64 ± 0.04

0.72 ± 0.08

0.026*

2.35 ± 0.17

2.91 ± 0.21

1.75 ± 0.44

0.139

PRL(μg/l)

1.73 ± 0.69

5.09 ± 1.85

3.79 ± 0.63

0.98

13.15 ± 1.55

18.21 ± 2.36

18.33 ± 8.65

0.358

rs2479102

Control

p-value

PCOS

p-value

CT

CC

TT

CT

CC

TT

Age (years)

33.2 ± 0.71

33.40 ± 1.06

32.80 ± 0.50

0.561

27.56 ± 0.74

23.33 ± 2.60

26.60 ± 0.63

0.218

BMI (kg/m2)

22.3 ± 0.55

22.94 ± 1.05

21.64 ± 0.26

0.197

23.40 ± 0.90

20.25 ± 1.88

23.48 ± 0.61

0.443

E2(pg/ml)

62.4 ± 7.30

47.53 ± 4.73

59.70 ± 4.79

0.525

190.30 ± 26.79

215.11 ± 31.41

240.79 ± 20.58

0.35

T(nm/l)

2.75 ± 0.33

1.20 ± 0.10

2.16 ± 0.29

0.191

3.24 ± 0.89

2.48 ± 0.52

3.36 ± 0.45

0.915

E2/T(ln)

21.9 ± 3.88

24.52 ± 3.66

64.40 ± 21.94

0.374

84.89 ± 12.45

89.30 ± 7.27

103.02 ± 14.29

0.702

LH(IU/l)

5.68 ± 0.58

5.06 ± 0.60

5.04 ± 0.35

0.619

14.86 ± 1.61

21.22 ± 5.02

15.56 ± 1.14

0.424

FSH(IU/l)

7.90 ± 0.61

9.02 ± 0.90

7.86 ± 0.34

0.129

6.94 ± 0.47

6.06 ± 0.30

6.32 ± 0.39

0.594

LH/FSH

0.80 ± 0.07

0.59 ± 0.07

0.67 ± 0.04

0.243

2.13 ± 0.18

3.55 ± 0.91

2.72 ± 0.22

0.092

PRL(μg/l)

4.64 ± 3.35

3.79 ± 0.63

5.76 ± 1.64

0.902

13.82 ± 1.57

22.26 ± 7.07

18.52 ± 2.49

0.38

rs2670139

Control

p-value

PCOS

p-value

CT

CC

TT

CT

CC

TT

Age (years)

33.2 ± 0.67

32.79 ± 1.11

32.66 ± 0.51

0.807

27.59 ± 0.71

25.50 ± 2.50

26.12 ± 0.60

0.318

BMI (kg/m2)

22.20 ± 0.5

22.33 ± 1.17

21.61 ± 0.25

0.458

23.40 ± 0.83

21.73 ± 2.01

23.20 ± 0.55

0.857

E2(pg/ml)

57.9 ± 6.98

60.14 ± 12.70

55.72 ± 3.41

0.89

214.98 ± 29.90

201.58 ± 49.11

250.40 ± 17.80

0.536

T(nm/l)

2.81 ± 0.31

2.15 ± 0.75

2.01 ± 0.26

0.198

3.37 ± 0.85

2.46 ± 0.90

6.37 ± 2.04

0.592

E2/T(ln)

22.0 ± 3.89

23.19 ± 7.55

66.16 ± 23.76

0.371

95.37 ± 15.37

86.28 ± 11.45

91.78 ± 11.84

0.979

LH(IU/l)

5.39 ± 1.00

4.84 ± 1.49

5.03 ± 0.35

0.786

14.86 ± 1.51

22.83 ± 8.24

17.63 ± 1.23

0.945

FSH(IU/l)

7.65 ± 1.10

8.23 ± 2.35

8.09 ± 0.36

0.129

6.57 ± 0.47

6.27 ± 0.38

6.73 ± 0.36

0.272

LH/FSH

0.78 ± 0.14

0.63 ± 0.16

0.64 ± 0.04

0.476

2.29 ± 0.19

3.73 ± 1.54

2.83 ± 0.20

0.138

PRL(μg/l)

2.53 ± 0.77

1.79 ± 0.04

4.63 ± 1.42

0.769

12.82 ± 1.37

16.33 ± 6.65

18.17 ± 2.16

0.294

  1. *P < 0.05. Statistical analyses were carried out by analysis of covariance to correct for age and BMI. Data are expressed as mean ± standard deviation. BMI body mass index, E2 estradiol, T testosterone, LH luteinizing hormone, FSH follicle-stimulating hormone