Fig. 3

Mutated POLE is involved in glucose metabolism of endometrial cancer patients. a Volcano plot of differentially expressed genes (DEGs) between the mutant and wild type POLE endometrial cancer samples. X represents the foldchange, Y represents the P value. Red dot represents upregulated genes while the blue dot represents downregulated genes. b–e Gene Set Enrichment Analysis (GSEA) of the global gene expression profiling between mutant and wild type POLE endometrial cancer samples. Gene sets annotated by GO terms were used in the analysis. Gene set representing glucose metabolism (c), isomerase activity (d), exonuclease activity (e) and intramolecular transferase activity (f) are rich in POLE mutants