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Table 2 Distribution of HTR2A genetic variations according to development of hypertension

From: Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study

SNP

Genotype

No Hypertension

(N = 4621), N (%)

Hypertension

(N = 1418), N (%)

p-value

Cohort A (N = 6039)

 rs7330636

GG

555 (85.9)

989 (89.2)

0.092

GA

89 (13.8)

115 (10.4)

AA

2 (0.3)

5 (0.5)

 rs9590999

CC

167 (25.1)

335 (29.2)

0.056

CT

354 (53.2)

545 (47.6)

TT

144 (21.7)

266 (23.2)

 rs2183057

AA

253 (38.0)

401 (34.9)

0.026

AG

331 (49.7)

553 (48.1)

GG

82 (12.3)

195 (17.0)

 rs4942595

TT

168 (25.2)

339 (29.5)

0.041

TC

354 (53.1)

541 (47.1)

CC

145 (21.7)

269 (23.4)

 rs4531630

AA

168 (25.3)

338 (29.6)

0.062

AG

344 (51.7)

584 (51.1)

GG

153 (23.0)

221 (12.2)

 rs17069883

AA

197 (29.5)

287 (25.0)

0.041

AC

341 (51.1)

594 (51.7)

CC

129 (19.3)

268 (23.3)

 rs4942578

CC

258 (38.7)

431 (37.5)

0.225

CA

320 (48.0)

530 (46.1)

AA

89 (13.3)

188 (16.4)

Cohort B (N = 7524)

 rs4942578

CC

1834 (39.2)

949 (40.2)

0.605

CA

2171 (46.5)

1089 (46.2)

AA

668 (14.3)

320 (13.6)

 rs985933

AA

1526 (32.8)

781 (33.2)

0.496

AG

2257 (48.5)

1154 (49.1)

GG

875 (18.8)

414 (17.6)

 rs4941573

TT

1184 (25.4)

565 (24.0)

0.196

TC

2314 (49.6)

1221 (51.8)

CC

1172 (25.1)

571 (24.2)

 rs6313

GG

1229 (26.3)

584 (24.8)

0.153

GA

2301 (49.2)

1218 (51.7)

AA

1143 (24.5)

556 (23.6)

 rs1328685

TT

4031 (86.3)

2054 (87.1)

0.259

TC

611 (13.1)

295 (12.5)

CC

31 (0.7)

9 (0.4)

 rs2567675

TT

2823 (60.4)

1483 (62.9)

0.124

TC

1616 (34.6)

762 (32.3)

CC

234 (5.0)

112 (4.8)