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Fig. 5 | BMC Medical Genetics

Fig. 5

From: An analysis of mutational signatures of synonymous mutations across 15 cancer types

Fig. 5

Comparison of RS scores between the datasets of hotspots and neutral synonymous mutations, non-hotspots. Hotspot represents hotspot mutations; 1000G represents neutral synonymous mutations of HMCGs in 1000G dataset; Non-hotspot represents non-hotspot mutations of HMCGs in TCGA dataset. The RS score of hotspot mutation dataset is significant higher than that neutral synonymous mutation dataset (p-value <2e-16). But there is no significant different between hotspot and non-hotspot datasets (p-value = 0.93) for RS score

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