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Table 3 Oxytocin stimulationa of myometrium contractility in the various reference and variant allele groups

From: Influence of oxytocin receptor single nucleotide sequence variants on contractility of human myometrium: an in vitro functional study

 

Oxytocin stimulation

(AUC after OXT addition/ AUC spontaneous contractility)

Reference group

Variant group

p-valuea

n/N

Mean ± SD

n/N

Mean ± SD

 

rs1042778

21/60

3.0 ± 1.3

39/60

3.5 ± 1.6

0.192

rs11706648

29/60

3.5 ± 1.7

31/60

3.2 ± 1.3

0.435

rs237888

54/59b

3.2 ± 1.2

5/59

5.5 ± 2.9

0.001c

rs4686301

32/60

3.4 ± 1.7

28/60

3.3 ± 1.4

0.697

rs53576

25/60

3.3 ± 0.9

35/60

3.4 ± 1.9

0.974

rs237895

18/60

3.4 ± 1.0

42/60

3.3 ± 1.7

0.843

rs237902

26/60

3.8 ± 1.8

34/60

3.3 ± 1.3

0.939

rs4686302

45/60

3.1 ± 1.3

15/60

4.1 ± 2.0

0.022c

  1. n Number of samples either in the reference group or in the variant allele group of a given single-nucleotide sequence variant
  2. N Number of samples for which data on a given variant are available
  3. SD Standard deviation
  4. a For each variant, the p-value represents the statistical significance of the difference between reference and variant groups as calculated using linear regression
  5. b One sample, in which the result of the allelic determination plot was undetermined, was excluded
  6. c Statistically significant