Criteria | Score |
---|---|
1.Representativeness of cases | |
 1.1 HCC and LC diagnosed according to acknowledged criteria. | 2 |
 1.2 Mentioned the diagnosed criteria but not specifically described. | 1 |
 1.3 Not Mentioned. | 0 |
2.Source of controls | |
 2.1 Cases and control from the same cohort | 1 |
  2.1.1 Defined HCC-free controls according to clinical, biochemical and serological parameters | 2 |
  2.1.2 Only defined HCC-free controls as CHB or LC but not described | 1 |
 2.2 Not described | 0 |
3.Sample size | |
 3.1 > 300 | 2 |
 3.2100–300 | 1 |
 3.3 < 100 | 0 |
4.Quality control of genotyping methods | |
 4.1 Repetition of partial/total tested samples with a different method | 2 |
 4.2 Repetition of partial/total tested samples with the same method | 1 |
 4.3 Not described | 0 |
5.Hardy-Weinberg equilibrium (HWE) | |
 5.1 Hardy-Weinberg equilibrium in control subjects | 1 |
 5.2 Hardy-Weinberg disequilibrium in control subjects | 0 |