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Table 1 Basic characteristics of all the studies included in the meta-analyses

From: The association between apolipoprotein E and gallstone disease: an updated meta-analysis

Study

Year of publication

Country/origin

GSD

Control

Diagnosis of GSD

NOS

n

Age

Male (%)

n

Age

Male (%)

Rollan et al. [25]

1994

Chile

109

48 ± 13

42.2

110

37 ± 12

43.6

US

5

Bertomeu et al. [12]

1996

Spain

160

59 ± 12.6

34.4

125

58 ± 11.2

34.4

CG/US

8

Niemi et al. [26]

1999

Finland

148

53

31.8

896

51.2

52.8

US

9

Ko et al. [27]

2000

USA

52

24.4 ± 4.4

0

104

25.2 ± 4.6

0

US

8

Abu et al. [28]

2002

Israel

10

–

–

124

–

–

US

7

Hasegawa et al. [29]

2003

Japan

79

55 ± 8.9

46.8

53

39 ± 7.3

60.4

VS/infrared

6

Jiang et al. [30]

2004

China

105

47.5 ± 11.0

74.3

274

47.9 ± 12.2

67.2

US

6

Dixit et al.a [31]

2006

India

207

44.7 ± 13.2

32.2

322

44.0 ± 11.5

36.0

US

7

Mella et al. [32]

2007

Chile

117

49 ± 12

–

122

40 ± 13

–

US

7

Mella et al. [32]

2007

Germany

184

63 ± 13

–

184

63 ± 13

–

US

7

Jaime et al. [33]

2010

Mexico

101

51.9 ± 11.2

13.9

101

51.7 ± 11.0

13.9

US

7

Pinheiro-Júnior et al.b [34]

2012

Brazil

107

46.6 ± 11.2

17.5

104

40.6 ± 9.7

20

US

7

Martinez-Lopez et al. [35]

2015

Mexico

90

40.6 ± 13.8

8

371

37.1 ± 11.5

–

US

7

Shabanzadeh et al.c [36]

2017

Denmark

162

60

34.1

2112

40

52

US

7

  1. Data for age were mainly presented as mean ± SD, or as median (range)
  2. a Data for age and gender for the GSD group were based on 214 patients with GSD
  3. b Data for age and gender were based on 114 subjects with cholelithiasis and 106 subjects without cholelithiasis
  4. c Data for age and gender were based on 504 subjects with GSD and 4992 subjects without GSD. Data for age represent the median age of the GSD group and the control group, respectively
  5. CG cholecystogram, Chole cholecystectomy, GSD gallstone disease, NDCD the National Danish Causes of Death, NDPR the National Danish Patient Registry, SD standard deviation, US ultrasound, VS visual inspection in cholecystectomy or liver transplantation