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Fig. 4 | BMC Medical Genetics

Fig. 4

From: HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia

Fig. 4

Correlation of DNA methylation and gene expression in NB cells and in NB samples. Gene expression heat maps showing the correlation of gene expression with the methylation status (annotation tracks on the left) in shHIF1A HYP vs shCTR HYP (a) and in shCTR HYP vs shCTR NX (b) pairwise contrasts. “q-value”: FDR. a and b Obtained with the R package “Pheatmap”. Gene expression heat maps show genes included in c “HIF1A signature in hypoxia” and d “Hypoxia signature”. Low risk (n = 40; in green) and High risk (n = 56; in red) patients of the GSE73517 data set were used to draw the heat maps.. Red boxes indicate clusters of Low risk and High risk samples. c and d Obtained on the R2: Genomics Analysis and Visualization Platform (http://r2.amc.nl). a-d The expression values were first Z-Score transformed and then used to perform hierarchical clustering based on Euclidean distances. Z-Score ranges are reported in the color keys

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