Skip to main content

Table 2 Results of the meta-analysis, heterogeneity test and Egger’s test

From: The association between interleukin-6 gene -174G/C single nucleotide polymorphism and sepsis: an updated meta-analysis with trial sequential analysis

 

Meta-analysis

Heterogeneity test

Egger’s test

 

no. of studies

OR (95% CI)

P value

I 2

P value

P value

The association between IL-6 -174G/C polymorphism and the risk of sepsis

Overall

      

 GC + CC vs GG

18

0.965 (0.782–1.192)

0.743

72.80%

< 0.001

0.694

 CC vs. GC + GG

18

0.992 (0.726–1.356)

0.96

72.90%

< 0.001

0.81

 GC vs. GG

16

0.950 (0.798–1.133)

0.57

52.00%

0.008

0.696

 CC vs.GG

16

0.992 (0.686–1.435)

0.966

77.80%

< 0.001

0.989

 C vs. G

16

1.014 (0.831–1.236)

0.894

84.20%

< 0.001

0.705

Non-adult

      

 GC + CC vs GG

9

0.796 (0.522–1.214)

0.29

78.40%

< 0.001

0.754

 CC vs. GC + GG

8

0.785 (0.614–1.003)

0.053

41.50%

0.101

0.337

 GC vs. GG

8

0.879 (0.578–1.336)

0.545

72.90%

0.001

0.694

 CC vs.GG

8

0.779 (0.427–1.421)

0.415

69.60%

0.002

0.38

 C vs. G

8

0.896 (0.643–1.248)

0.516

80.10%

< 0.001

0.475

Adult

      

 GC + CC vs GG

9

1.112 (0.900–1.374)

0.324

59.20%

0.012

0.464

 CC vs. GC + GG

10

1.080 (0.700–1.666)

0.73

79.50%

< 0.001

0.73

 GC vs. GG

9

0.988 (0.874–1.117)

0.851

0%

0.711

0.816

 CC vs.GG

9

1.208 (0.766–1.905)

0.416

79.60%

< 0.001

0.904

 C vs. G

9

1.124 (0.868–1.455)

0.375

86.40%

< 0.001

0.63

Caucasian

      

 GC + CC vs GG

16

0.857 (0.699–1.050)

0.136

65.20%

< 0.001

0.725

 CC vs. GC + GG

17

0.892 (0.771–1.033)

0.127

6.70%

0.376

0.712

 GC vs. GG

15

0.912 (0.756–1.099)

0.333

52.50%

0.009

0.954

 CC vs.GG

15

0.853 (0.643–1.132)

0.271

55.00%

0.005

0.962

 C vs. G

15

0.913 (0.787–1.059)

0.228

66.20%

< 0.001

0.821

Healthy control

      

 GC + CC vs GG

10

0.919 (0.686–1.232)

0.574

78.60%

< 0.001

0.709

 CC vs. GC + GG

10

0.985 (0.623–1.557)

0.949

84.30%

< 0.001

0.979

 GC vs. GG

10

0.894 (0.791–1.010)

0.072

47.30%

0.047

0.871

 CC vs.GG

10

0.896 (0.531–1.511)

0.681

85.50%

< 0.001

0.995

 C vs. G

10

0.964 (0.726–1.282)

0.803

89.30%

< 0.001

0.747

Mendelian population

      

 GC + CC vs GG

13

0,947 (0.768–1.167)

0.607

66.60%

< 0.001

0.701

 CC vs. GC + GG

13

0.903 (0.777–1.049)

0.101

27.7%%

0.165

0.807

 GC vs. GG

13

0.971 (0.805–1.171)

0.758

53.10%

0.012

0.645

 CC vs.GG

13

0.880 (0.647–1.197)

0.416

61.50%

0.002

0.698

 C vs. G

13

0.945 (0.806–1.109)

0.489

71.00%

< 0.001

0.81

The association between IL-6 -174G/C polymorphism and the mortality of sepsis

 

Overall

      

 GC + CC vs GG

10

1.050 (0.705–1.563)

0.812

57.90%

0.011

0.059

 CC vs. GC + GG

10

1.299 (0.665–2.538)

0.444

62.20%

0.005

0.173

 GC vs. GG

10

1.045 (0.709–1.540)

0.825

51.10%

0.031

0.143

 CC vs.GG

10

1.340 (0.611–2.939)

0.465

67.00%

0.001

0.113

 C vs. G

10

1.103 (0.795–1.531)

0.558

69.50%

0.001

0.134

Non-adult

      

 GC + CC vs GG

4

1.434 (0.810–2.538)

0.216

0%

0.449

0.883

 CC vs. GC + GG

4

2.957 (1.442–6.066)

0.003

0%

0.434

0.684

 GC vs. GG

4

1.098 (0.588–2.050)

0.77

0%

0.746

0.871

 CC vs.GG

4

3.221 (1.431–7.250)

0.005

3%

0.38

0.872

 C vs. G

4

1.631 (1.101–2.416)

0.015

31.90%

0.221

0.783

Adult

      

 GC + CC vs GG

6

1.005 (0.593–1.705)

0.985

73.10%

0.002

0.126

 CC vs. GC + GG

6

1.204 (0.342–4.236)

0.772

86.50%

< 0.001

0.486

 GC vs. GG

6

1.078 (0.639–1.818)

0.778

70.30%

0.005

0.127

 CC vs.GG

6

0.868 (0.341–2.208)

0.766

66.60%

0.01

0.302

 C vs. G

6

0.940 (0.654–1.352)

0.739

70.90%

0.004

0.377

Caucasian

      

 GC + CC vs GG

9

1.206 (0.723–2.007)

0.474

65.70%

0.003

0.094

 CC vs. GC + GG

9

1.376 (0.656–2.884)

0.399

67.90%

0.002

0.097

 GC vs. GG

9

1.143 (0.713–1.834)

0.579

55.50%

0.021

0.174

 CC vs.GG

9

1.430 (0.598–3.420)

0.422

71.30%

< 0.001

0.071

 C vs. G

9

1.180 (0.802–1.737)

0.401

73.50%

< 0.001

0.101