From: Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis
Polymoyphisms | Population | Genetic model | Genetic model | No. of studies | Test of association | Model | Test of heterogeneity | Egger’s test(P) | |||
---|---|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | P-value | P-value | I2 (%) | |||||||
rs7975232 | All | C vs. A | Allelic | 9 | 1.19 | 1.06~1.34 | 0.004 | F | 0.170 | 32.5 | 0.676 |
VDR ApaI |  | CC vs. CA + AA | Dominant | 9 | 1.35 | 1.09~1.69 | 0.008 | F | 0.310 | 16.0 | 0.145 |
CC + CA vs. AA | Recessive | 9 | 1.20 | 1.01~1.42 | 0.042 | F | 0.050 | 50.0 | 0.132 | ||
Asian | C vs. A | Allelic | 5 | 1.21 | 1.04~1.42 | 0.016 | F | 0.060 | 57.9 | 0.963 | |
CC vs. CA + AA | Dominant | 5 | 1.70 | 1.26~2.29 | 0.001 | F | 0.700 | 0.0 | 0.265 | ||
CC + CA vs. AA | Recessive | 5 | 1.10 | 0.88~1.37 | 0.411 | R | 0.018 | 66.4 | 0.234 | ||
Caucasian | C vs. A | Allelic | 4 | 1.17 | 0.98~1.38 | 0.053 | F | 0.849 | 0.0 | 0.452 | |
CC vs. CA + AA | Dominant | 4 | 1.11 | 0.83~1.48 | 0.470 | F | 0.578 | 0.0 | 0.145 | ||
CC + CA vs. AA | Recessive | 4 | 1.32 | 0.89~1.46 | 0.084 | F | 0.683 | 0.0 | 0.247 | ||
rs1544410 | All | G vs. A | Allelic | 8 | 1.11 | 0.91~1.37 | 0.307 | R | 0.030 | 54.8 | 0.462 |
VDR BsmI |  | GG vs. GA + AA | Dominant | 8 | 0.94 | 0.75~1.17 | 0.556 | F | 0.280 | 20 | 0.563 |
GG + GA vs. AA | Recessive | 8 | 1.08 | 0.45~2.62 | 0.860 | R | 0.030 | 57 | 0.245 | ||
Asian | G vs. A | Allelic | 5 | 1.27 | 1.06~1.53 | 0.011 | F | 0.114 | 46.3 | 0.256 | |
GG vs. CA + AA | Dominant | 5 | 1.89 | 1.08~3.30 | 0.026 | R | 0.027 | 63.5 | 0.356 | ||
GG + GA vs. AA | Recessive | 5 | 1.54 | 0.63~3.76 | 0.342 | R | 0.001 | 86.1 | 0.235 | ||
Caucasian | G vs. A | Allelic | 3 | 0.95 | 0.78~1.15 | 0.597 | F | 0.180 | 41.7 | 0.751 | |
GG vs. CA + AA | Dominant | 3 | 0.57 | 0.27~1.18 | 0.128 | R | 0.002 | 84.3 | 0.156 | ||
GG + GA vs. AA | Recessive | 3 | 0.46 | 0.35~1.28 | 0.136 | R | 0.069 | 62.7 | 0.237 | ||
rs731236 | All | C vs. T | Allelic | 10 | 1.14 | 0.93~1.40 | 0.218 | R | 0.001 | 67.5 | 0.452 |
VDR TaqI |  | CC vs. TC + TT | Dominant | 10 | 1.20 | 0.84~1.71 | 0.322 | R | 0.006 | 61.1 | 0.564 |
CC + TC vs. TT | Recessive | 10 | 1.07 | 0.81~1.41 | 0.628 | R | 0.003 | 63.5 | 0.521 | ||
Asian | C vs. T | Allelic | 6 | 1.09 | 0.85~1.41 | 0.493 | R | 0.034 | 58.6 | 0.426 | |
CC vs. CT + TT | Dominant | 6 | 1.46 | 0.81~2.64 | 0.207 | R | 0.008 | 68.2 | 0.359 | ||
CC + CT vs. TT | Recessive | 6 | 1.02 | 0.83~1.24 | 0.858 | F | 0.128 | 41.6 | 0.215 | ||
Caucasian | C vs. A | Allelic | 4 | 1.19 | 0.82~1.74 | 0.359 | R | 0.002 | 79.5 | 0.568 | |
CC vs. CA + AA | Dominant | 4 | 1.01 | 0.63~1.63 | 0.961 | R | 0.062 | 59.1 | 0.356 | ||
CC + CA vs. AA | Recessive | 4 | 1.15 | 0.63~2.10 | 0.654 | R | 0.001 | 80.8 | 0.628 | ||
rs2228570 | All | T vs. C | Allelic | 7 | 1.04 | 0.83~1.30 | 0.715 | R | 0.050 | 52.3 | 0.539 |
VDR FokI |  | TT vs. CT + CC | Dominant | 7 | 0.90 | 0.65~1.24 | 0.521 | F | 0.291 | 18.1 | 0.759 |
TT + CT vs. CC | Recessive | 7 | 1.06 | 0.88~1.27 | 0.569 | F | 0.149 | 36.6 | 0.349 | ||
Asian | T vs. C | Allelic | 5 | 1.13 | 0.94~1.37 | 0.190 | F | 0.150 | 40.8 | 0.564 | |
TT vs. CT + CC | Dominant | 5 | 1.26 | 0.76~2.08 | 0.374 | F | 0.785 | 0.0 | 0.486 | ||
TT + CT vs. CC | Recessive | 5 | 1.15 | 0.92~1.44 | 0.233 | F | 0.136 | 42.8 | 0.843 | ||
Caucasian | C vs. A | Allelic | 2 | 0.85 | 0.68~1.07 | 0.173 | F | 0.124 | 57.7 | – | |
CC vs. CA + AA | Dominant | 2 | 0.65 | 0.29~1.44 | 0.284 | R | 0.084 | 66.5 | – | ||
CC + CA vs. AA | Recessive | 2 | 0.88 | 0.63~1.23 | 0.465 | F | 0.352 | 0.0 | – | ||
rs757343 | All (Asian) | A vs. G | Allelic | 3 | 1.04 | 0.81~1.34 | 0.734 | F | 0.939 | 0.0 | 0.428 |
VDR Tru9I |  | AA vs. AG + GG | Dominant | 3 | 1.09 | 0.52~2.28 | 0.830 | F | 0.753 | 0.0 | 0.740 |
AA+AG vs. GG | Recessive | 3 | 1.05 | 0.79~1.39 | 0.759 | F | 0.899 | 0.0 | 0.445 |