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Table 6 Summary of meta-analysis on VDR gene variants and polycystic ovarian syndrome (PCOS) susceptibility

From: Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis

Polymoyphisms

Population

Genetic model

Genetic model

No. of studies

Test of association

Model

Test of heterogeneity

Egger’s test(P)

OR

95% CI

P-value

P-value

I2 (%)

rs7975232

All

C vs. A

Allelic

9

1.19

1.06~1.34

0.004

F

0.170

32.5

0.676

VDR ApaI

 

CC vs. CA + AA

Dominant

9

1.35

1.09~1.69

0.008

F

0.310

16.0

0.145

CC + CA vs. AA

Recessive

9

1.20

1.01~1.42

0.042

F

0.050

50.0

0.132

Asian

C vs. A

Allelic

5

1.21

1.04~1.42

0.016

F

0.060

57.9

0.963

CC vs. CA + AA

Dominant

5

1.70

1.26~2.29

0.001

F

0.700

0.0

0.265

CC + CA vs. AA

Recessive

5

1.10

0.88~1.37

0.411

R

0.018

66.4

0.234

Caucasian

C vs. A

Allelic

4

1.17

0.98~1.38

0.053

F

0.849

0.0

0.452

CC vs. CA + AA

Dominant

4

1.11

0.83~1.48

0.470

F

0.578

0.0

0.145

CC + CA vs. AA

Recessive

4

1.32

0.89~1.46

0.084

F

0.683

0.0

0.247

rs1544410

All

G vs. A

Allelic

8

1.11

0.91~1.37

0.307

R

0.030

54.8

0.462

VDR BsmI

 

GG vs. GA + AA

Dominant

8

0.94

0.75~1.17

0.556

F

0.280

20

0.563

GG + GA vs. AA

Recessive

8

1.08

0.45~2.62

0.860

R

0.030

57

0.245

Asian

G vs. A

Allelic

5

1.27

1.06~1.53

0.011

F

0.114

46.3

0.256

GG vs. CA + AA

Dominant

5

1.89

1.08~3.30

0.026

R

0.027

63.5

0.356

GG + GA vs. AA

Recessive

5

1.54

0.63~3.76

0.342

R

0.001

86.1

0.235

Caucasian

G vs. A

Allelic

3

0.95

0.78~1.15

0.597

F

0.180

41.7

0.751

GG vs. CA + AA

Dominant

3

0.57

0.27~1.18

0.128

R

0.002

84.3

0.156

GG + GA vs. AA

Recessive

3

0.46

0.35~1.28

0.136

R

0.069

62.7

0.237

rs731236

All

C vs. T

Allelic

10

1.14

0.93~1.40

0.218

R

0.001

67.5

0.452

VDR TaqI

 

CC vs. TC + TT

Dominant

10

1.20

0.84~1.71

0.322

R

0.006

61.1

0.564

CC + TC vs. TT

Recessive

10

1.07

0.81~1.41

0.628

R

0.003

63.5

0.521

Asian

C vs. T

Allelic

6

1.09

0.85~1.41

0.493

R

0.034

58.6

0.426

CC vs. CT + TT

Dominant

6

1.46

0.81~2.64

0.207

R

0.008

68.2

0.359

CC + CT vs. TT

Recessive

6

1.02

0.83~1.24

0.858

F

0.128

41.6

0.215

Caucasian

C vs. A

Allelic

4

1.19

0.82~1.74

0.359

R

0.002

79.5

0.568

CC vs. CA + AA

Dominant

4

1.01

0.63~1.63

0.961

R

0.062

59.1

0.356

CC + CA vs. AA

Recessive

4

1.15

0.63~2.10

0.654

R

0.001

80.8

0.628

rs2228570

All

T vs. C

Allelic

7

1.04

0.83~1.30

0.715

R

0.050

52.3

0.539

VDR FokI

 

TT vs. CT + CC

Dominant

7

0.90

0.65~1.24

0.521

F

0.291

18.1

0.759

TT + CT vs. CC

Recessive

7

1.06

0.88~1.27

0.569

F

0.149

36.6

0.349

Asian

T vs. C

Allelic

5

1.13

0.94~1.37

0.190

F

0.150

40.8

0.564

TT vs. CT + CC

Dominant

5

1.26

0.76~2.08

0.374

F

0.785

0.0

0.486

TT + CT vs. CC

Recessive

5

1.15

0.92~1.44

0.233

F

0.136

42.8

0.843

Caucasian

C vs. A

Allelic

2

0.85

0.68~1.07

0.173

F

0.124

57.7

–

CC vs. CA + AA

Dominant

2

0.65

0.29~1.44

0.284

R

0.084

66.5

–

CC + CA vs. AA

Recessive

2

0.88

0.63~1.23

0.465

F

0.352

0.0

–

rs757343

All (Asian)

A vs. G

Allelic

3

1.04

0.81~1.34

0.734

F

0.939

0.0

0.428

VDR Tru9I

 

AA vs. AG + GG

Dominant

3

1.09

0.52~2.28

0.830

F

0.753

0.0

0.740

AA+AG vs. GG

Recessive

3

1.05

0.79~1.39

0.759

F

0.899

0.0

0.445

  1. F fixed effects model, R random effects model