Table 4 Stratified analysis of the association of ATM polymorphisms with cancer under dominant model
From: ATM rs189037 (G > A) polymorphism increased the risk of cancer: an updated meta-analysis
Subgroup analysis | Rs189037 | |||||
|---|---|---|---|---|---|---|
n | OR | 95% CI | p z | I2(%) | p h | |
Overall | 15 | 1.207 | 1.090–1.337 | < 0.001 | 40.9 | 0.050 |
Ethnicity | ||||||
East Asian | 13 | 1.200 | 1.067–1.350 | 0.002 | 49.2 | 0.023 |
Latino | 1 | 1.254 | 1.007–1.563 | 0.043 | – | – |
Caucasian | 1 | 1.201 | 0.668–2.159 | 0.540 | – | – |
Source of controls | ||||||
Hospital-based | 13 | 1.189 | 1.061–1.332 | 0.003 | 46.3 | 0.034 |
Population-based | 2 | 1.362 | 1.095–1.695 | 0.006 | 0.0 | 0.650 |
Type of cancer | ||||||
lung cancer | 5 | 1.158 | 1.005–1.334 | 0.043 | 19.9 | 0.288 |
breast cancer | 2 | 1.341 | 1.035–1.737 | 0.026 | 43.3 | 0.184 |
oral cancer | 1 | 1.931 | 1.456–2.559 | < 0.001 | – | – |
leukemia | 1 | 1.239 | 0.786–1.953 | 0.355 | – | – |
thyroid carcinoma | 4 | 1.094 | 0.897–1.335 | 0.374 | 20.3 | 0.288 |
glioma | 1 | 1.042 | 0.700–1.551 | 0.839 | – | – |
colorectal cancer | 1 | 1.153 | 0.931–1.429 | 0.192 | – | – |