Notch polymorphisms associated with sensitivity of noise induced hearing loss among Chinese textile factory workers

Table 3 Distribution of three polymorphisms and the association with NIHL

Genetic models	Genotypes	Cases		Controls		P ^a	Adjusted OR
Genetic models	Genotypes	n = 535	%	n = 535	%	P ^a	(95% CI)^b
rs3124594
Codominant	AA	3	0.6	12	2.2	< 0.001	1.00 (Ref.)
	AG	54	10.1	109	20.4		2.02(0.54–7.51)
	GG	478	89.3	414	77.4		4.70(1.31–16.87)
Dominant	AG/AA	57	107.0	121	22.6	< 0.001	1.00 (Ref.)
	GG	478	89.3	414	77.4		2.45(1.74–3.45)
Recessive	AA	3	0.6	12	2.2	0.019	1.00 (Ref.)
	GG/AG	532	99.4	523	97.8		4.19 (1.17–15.04)
Alleles	A	60	5.6	133	12.4	< 0.001	1.00 (Ref.)
	G	1010	94.4	937	87.6		2.39 (1.74–3.29)
rs3124599
Codominant	GG	78	14.6	76	14.2	0.343	1.00 (Ref.)
	AG	234	43.7	257	48.0		0.88 (0.61–1.27)
	AA	223	41.7	202	37.8		1.07 (0.74–1.55)
Dominant	GG/AG	312	58.3	333	62.2	0.190	1.00 (Ref.)
	AA	223	41.7	202	37.8		1.18(0.92–1.51)
Recessive	GG	78	14.6	76	14.2	0.862	1.00 (Ref.)
	AA/AG	457	85.4	459	85.8		0.97 (0.69–1.36)
Alleles	G	390	36.4	409	38.2	0.396	1.00 (Ref.)
	A	680	63.6	661	61.8		1.08 (0.91–1.29)
rs3124603
Codominant	CC	395	73.8	430	80.4	0.003	1.00 (Ref.)
	CT	134	25.0	92	17.2		0.51 (0.19–1.35)
	TT	6	1.1	13	2.4		1.59 (1.18–2.14)
Dominant	CC	395	73.8	430	80.4	0.011	1.00 (Ref.)
	CT/TT	140	26.2	105	19.6		1.46 (1.09–1.94)
Recessive	TT	6	1.1	13	2.4	0.105	1.00 (Ref.)
	CC/CT	529	98.9	522	97.6		2.17 (0.82–5.76)
Alleles	C	924	86.4	952	89.0	0.066	1.00 (Ref.)
	T	146	13.6	118	11.0		1.28 (0.99–1.66)

^aTwo-sided χ² test
^bAdjusted for age, sex, alcohol and tobacco consumption habits in logistic regression model

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