Skip to main content
Fig. 1 | BMC Medical Genetics

Fig. 1

From: Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice

Fig. 1

Differential gene expression of MuRF1−/− right ventricle after three weeks CH exposure. a Summary of how differentially expressed genes in hypoxia-challenged MuRF1−/− RV tissue compared to MuRF1+/+ were identified. b Top 35 increased unique genes (> 2-fold) and top 31 decreased unique genes (<− 2-fold) compared to MuRF1+/+ hearts. Asterisk (*) designates same/related sequence for duplicate gene name. c Identification of transcription factors with binding sites of top 35 increased and top 31 decreased genes using TRANSFAC® FMatch. The number of genes in dataset and enrichment (sites/sequence ratio) for each transcription factor is calculated to the right. d STRING analysis of differentially expressed genes for known interactions and e STRING analysis pathway ID statistics. MuRF1−/−: N = 5 biological replicates; MuRF1+/+: N = 6 biological replicates

Back to article page