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Fig. 1 | BMC Medical Genetics

Fig. 1

From: First case report of malignant peritoneal mesothelioma and oral verrucous carcinoma in a patient with a germline PTEN mutation: a combination of extremely rare diseases with probable further implications

Fig. 1

(a) Timeline. Relevant events, depicted in the clinical course of the patient (respective age is given in years) with focus on diagnosis and interventions, are represented in a chronological order (time line is not true to scale, colors on both sides correspond to each other). (b) Pedigree chart. The index patient presented with macrocephaly, typical mucocutaneous lesions and a history of different tumor diseases. He was diagnosed with thyroid cancer at the age of 36 years and with a verrucous carcinoma (VC) and malignant peritoneal mesothelioma (MPM) at the age of 42 years. The combination of the clinical symptoms subsequently led to the clinical diagnosis of PTEN-hamartoma tumor syndrome (PHTS). The patient stated that one of his sons and his father were also macrocephalic (III:2, I:1). Another son was reported to have cutaneous papillomatosis (III:1). The arrow marks the index patient, squares males and circles females. Filled symbols indicate clinical symptoms that support the diagnosis of PHTS

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