Fig. 1From: First case report of malignant peritoneal mesothelioma and oral verrucous carcinoma in a patient with a germline PTEN mutation: a combination of extremely rare diseases with probable further implications(a) Timeline. Relevant events, depicted in the clinical course of the patient (respective age is given in years) with focus on diagnosis and interventions, are represented in a chronological order (time line is not true to scale, colors on both sides correspond to each other). (b) Pedigree chart. The index patient presented with macrocephaly, typical mucocutaneous lesions and a history of different tumor diseases. He was diagnosed with thyroid cancer at the age of 36 years and with a verrucous carcinoma (VC) and malignant peritoneal mesothelioma (MPM) at the age of 42 years. The combination of the clinical symptoms subsequently led to the clinical diagnosis of PTEN-hamartoma tumor syndrome (PHTS). The patient stated that one of his sons and his father were also macrocephalic (III:2, I:1). Another son was reported to have cutaneous papillomatosis (III:1). The arrow marks the index patient, squares males and circles females. Filled symbols indicate clinical symptoms that support the diagnosis of PHTSBack to article page