Table 2 Top SNPs associated with blood pressure dipping (night-to-day blood pressure ratio) in GENRES and replication in DYNAMIC and DILGOM
From: Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients
Discovery GWAS in GENRES | Replication in DYNAMIC | Replication in DILGOM | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | Chr | Gene | EA/ OA | SBP/ DBP | EAF | n | β (%) | P | EAF | n | β (%) | P | Direction | EAF | n | β (%) | P | Direction |
rs4905794 | 14 | BCL11B | G/A | SBP | 0.08 | 204 | −4.8 | 9.6 × 10−9 | 0.10 | 183 | −0.8 | 0.4 | same | 0.11 | 180 | 0.9 | 0.3 | opposite |
eQTL | DBP | −4.3 | 2.2 × 10−6 | −1.6 | 0.13 | same | 1.0 | 0.4 | opposite | |||||||||
rs2119704 | 14 | GPR65 | A/C | SBP | 0.07 | 204 | −2.9 | 1.7 × 10−3 | 0.06 | 183 | 1.4 | 0.2 | opposite | 0.06 | 180 | 0.9 | 0.5 | opposite |
eQTL | DBP | −4.6 | 3.4 × 10−6 | 1.1 | 0.4 | opposite | −0.4 | 0.8 | same | |||||||||
rs10817396 | 9 | SNX30 | G/A | SBP | 0.17 | 204 | 1.9 | 2.4 × 10−3 | 0.18 | 183 | 0.3 | 0.7 | same | 0.20 | 180 | 0.3 | 0.7 | same |
intron | DBP | 3.1 | 5.5 × 10−6 | −0.1 | 0.9 | opposite | 0.6 | 0.6 | same | |||||||||
rs16984571 | 2 | KCNS3 | G/A | SBP | 0.15 | 201 | −2.7 | 5.6 × 10−6 | 0.14 | 183 | −0.8 | 0.3 | same | 0.13 | 180 | −1.2 | 0.2 | same |
intron | DBP | −2.5 | 1.1 × 10−4 | −0.7 | 0.4 | same | −1.0 | 0.4 | same | |||||||||
rs12509878 | 4 | lncRNA | C/A | SBP | 0.34 | 203 | −1.5 | 9.8 × 10−4 | 0.37 | 183 | 1.3 | 0.03 | opposite | 0.37 | 180 | −1.4 | 0.03 | same |
intron | DBP | −2.2 | 5.8 × 10−6 | 1.1 | 0.11 | opposite | −1.6 | 0.05 | same | |||||||||
rs1230361 | 5 | ERAP2 | A/C | SBP | 0.47 | 204 | 1.4 | 1.1 × 10−3 | 0.49 | 183 | 0.5 | 0.4 | same | 0.45 | 180 | −0.6 | 0.3 | opposite |
intron/eQTL | DBP | 2.1 | 9.3 × 10−6 | 0.1 | 0.9 | same | −0.7 | 0.3 | opposite | |||||||||