Genetic contrasts | Group and subgroups | Studies Number | Q test P-value | Model selected | OR (95%CI) | P |
---|---|---|---|---|---|---|
GSTM1 | ||||||
 - vs + | Overall | 15 | 0.23 | Fixed | 1.00 (0.92,1.09) | 0.91 |
Caucasian | 11 | 0.16 | Fixed | 1.02 (0.92,1.12) | 0.72 | |
Asian | 3 | 0.23 | Fixed | 0.95 (0.78,1.17) | 0.65 | |
Hospital-based | 11 | 0.43 | Fixed | 1.01 (0.92,1.11) | 0.85 | |
Population-based | 4 | 0.06 | Random | 0.87 (0.57,1.33) | 0.52 | |
High quality | 12 | 0.42 | Fixed | 1.02 (0.93,1.11) | 0.72 | |
GSTT1 | ||||||
 - vs + | Overall | 15 | 0.0006 | Random | 1.09 (0.90,1.33) | 0.38 |
Caucasian | 11 | 0.30 | Fixed | 1.00 (0.88,1.13) | 0.97 | |
Asian | 3 | 0.005 | Random | 1.73 (0.91,3.28) | 0.09 | |
Hospital-based | 11 | 0.68 | Fixed | 1.01 (0.90,1.14) | 0.84 | |
Population-based | 4 | 0.01 | Random | 1.62 (0.90,2.91) | 0.11 | |
High quality | 12 | 0.002 | Random | 1.09 (0.90,1.32) | 0.39 | |
Dual-null genotype for GSTM1/GSTT1 | ||||||
 - vs + | Overall | 9 | 0.08 | Random | 1.26 (1.00,1.59) | 0.05 |
Caucasian | 5 | 0.48 | Fixed | 1.05 (0.89,1.23) | 0.58 | |
Asian | 3 | 0.22 | Fixed | 1.72 (1.24,2.38) | 0.001 | |
Hospital-based | 5 | 0.97 | Fixed | 1.07 (0.91,1.25) | 0.43 | |
Population-based | 4 | 0.12 | Fixed | 1.70 (1.25,2.32) | 0.0007 | |
High quality | 6 | 0.10 | Fixed | 1.17 (1.01,1.36) | 0.03 | |
GSTP1 | ||||||
 A vs G | Overall | 6 | 0.02 | Random | 0.93 (0.77,1.11) | 0.41 |
Caucasian | 3 | 0.06 | Random | 1.02 (0.80,1.31) | 0.85 | |
Asian | 2 | 0.27 | Fixed | 0.72 (0.58,0.90) | 0.003 | |
Hospital-based | 4 | 0.10 | Fixed | 0.97 (0.87,1.08) | 0.59 | |
Population-based | 2 | 0.02 | Random | 0.82 (0.52,1.29) | 0.39 | |
High quality | 6 | 0.02 | Random | 0.93 (0.77,1.11) | 0.41 | |
 AA vs AG + GG | Overall | 8 | <0.00001 | Random | 0.74 (0.55,1.00) | 0.05 |
Caucasian | 5 | <0.00001 | Random | 0.72 (0.46,1.13) | 0.15 | |
Asian | 2 | 0.19 | Fixed | 0.66 (0.50,0.88) | 0.004 | |
Hospital-based | 6 | <0.00001 | Random | 0.74 (0.51,1.07) | 0.11 | |
Population-based | 2 | 0.02 | Random | 0.77 (0.41,1.42) | 0.40 | |
High quality | 8 | <0.00001 | Random | 0.74 (0.55,1.00) | 0.05 | |
 GG vs AG + AA | Overall | 6 | 0.22 | Fixed | 1.14 (0.93,1.40) | 0.22 |
Caucasian | 3 | 0.07 | Random | 0.98 (0.58,1.66) | 0.95 | |
Asian | 2 | 0.51 | Fixed | 1.49 (0.90,2.49) | 0.12 | |
Hospital-based | 4 | 0.16 | Fixed | 1.10 (0.87,1.40) | 0.43 | |
Population-based | 2 | 0.21 | Fixed | 1.26 (0.83,1.91) | 0.28 | |
High quality | 6 | 0.22 | Fixed | 1.14 (0.93,1.40) | 0.22 | |
GSTM1-TNM | ||||||
 - vs + | Overall | 4 | <0.0001 | Random | 0.72 (0.30,1.70) | 0.45 |
Caucasian | 1 | – | Fixed | 1.68 (0.88,3.24) | 0.12 | |
Asian | 2 | <0.0001 | Random | 0.55 (0.11,2.70) | 0.46 | |
Hospital-based | 2 | 0.39 | Fixed | 1.32 (0.95,1.83) | 0.10 | |
Population-based | 2 | 0.23 | Fixed | 0.30 (0.18,0.51) | <0.0001 | |
High quality | 4 | <0.0001 | Random | 0.72 (0.30,1.70) | 0.45 | |
GSTT1-TNM | ||||||
 - vs + | Overall | 5 | 0.19 | Fixed | 0.56 (0.41,0.78) | 0.0006 |
Caucasian | 2 | 0.36 | Fixed | 0.56 (0.31,1.01) | 0.06 | |
Asian | 2 | 0.06 | Random | 0.48 (0.21,1.12) | 0.09 | |
Hospital-based | 3 | 0.55 | Fixed | 0.64 (0.42,0.97) | 0.03 | |
Population-based | 2 | 0.05 | Random | 0.54 (0.16,1.87) | 0.33 | |
High quality | 4 | 0.13 | Fixed | 0.59 (0.41,0.85) | 0.004 |