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Table 4 Meta-analysis of the association of GSTM1- and GSTT1-null genotypes and GSTP1 with RCC risk and the relationship between GSTM1, GSTT1 and clinical TNM stages of RCC

From: A systematic review and meta-analyses of the relationship between glutathione S-transferase gene polymorphisms and renal cell carcinoma susceptibility

Genetic contrasts

Group and subgroups

Studies Number

Q test P-value

Model selected

OR (95%CI)

P

GSTM1

 - vs +

Overall

15

0.23

Fixed

1.00 (0.92,1.09)

0.91

Caucasian

11

0.16

Fixed

1.02 (0.92,1.12)

0.72

Asian

3

0.23

Fixed

0.95 (0.78,1.17)

0.65

Hospital-based

11

0.43

Fixed

1.01 (0.92,1.11)

0.85

Population-based

4

0.06

Random

0.87 (0.57,1.33)

0.52

High quality

12

0.42

Fixed

1.02 (0.93,1.11)

0.72

GSTT1

 - vs +

Overall

15

0.0006

Random

1.09 (0.90,1.33)

0.38

Caucasian

11

0.30

Fixed

1.00 (0.88,1.13)

0.97

Asian

3

0.005

Random

1.73 (0.91,3.28)

0.09

Hospital-based

11

0.68

Fixed

1.01 (0.90,1.14)

0.84

Population-based

4

0.01

Random

1.62 (0.90,2.91)

0.11

High quality

12

0.002

Random

1.09 (0.90,1.32)

0.39

Dual-null genotype for GSTM1/GSTT1

 - vs +

Overall

9

0.08

Random

1.26 (1.00,1.59)

0.05

Caucasian

5

0.48

Fixed

1.05 (0.89,1.23)

0.58

Asian

3

0.22

Fixed

1.72 (1.24,2.38)

0.001

Hospital-based

5

0.97

Fixed

1.07 (0.91,1.25)

0.43

Population-based

4

0.12

Fixed

1.70 (1.25,2.32)

0.0007

High quality

6

0.10

Fixed

1.17 (1.01,1.36)

0.03

GSTP1

 A vs G

Overall

6

0.02

Random

0.93 (0.77,1.11)

0.41

Caucasian

3

0.06

Random

1.02 (0.80,1.31)

0.85

Asian

2

0.27

Fixed

0.72 (0.58,0.90)

0.003

Hospital-based

4

0.10

Fixed

0.97 (0.87,1.08)

0.59

Population-based

2

0.02

Random

0.82 (0.52,1.29)

0.39

High quality

6

0.02

Random

0.93 (0.77,1.11)

0.41

 AA vs AG + GG

Overall

8

<0.00001

Random

0.74 (0.55,1.00)

0.05

Caucasian

5

<0.00001

Random

0.72 (0.46,1.13)

0.15

Asian

2

0.19

Fixed

0.66 (0.50,0.88)

0.004

Hospital-based

6

<0.00001

Random

0.74 (0.51,1.07)

0.11

Population-based

2

0.02

Random

0.77 (0.41,1.42)

0.40

High quality

8

<0.00001

Random

0.74 (0.55,1.00)

0.05

 GG vs AG + AA

Overall

6

0.22

Fixed

1.14 (0.93,1.40)

0.22

Caucasian

3

0.07

Random

0.98 (0.58,1.66)

0.95

Asian

2

0.51

Fixed

1.49 (0.90,2.49)

0.12

Hospital-based

4

0.16

Fixed

1.10 (0.87,1.40)

0.43

Population-based

2

0.21

Fixed

1.26 (0.83,1.91)

0.28

High quality

6

0.22

Fixed

1.14 (0.93,1.40)

0.22

GSTM1-TNM

 - vs +

Overall

4

<0.0001

Random

0.72 (0.30,1.70)

0.45

Caucasian

1

–

Fixed

1.68 (0.88,3.24)

0.12

Asian

2

<0.0001

Random

0.55 (0.11,2.70)

0.46

Hospital-based

2

0.39

Fixed

1.32 (0.95,1.83)

0.10

Population-based

2

0.23

Fixed

0.30 (0.18,0.51)

<0.0001

High quality

4

<0.0001

Random

0.72 (0.30,1.70)

0.45

GSTT1-TNM

 - vs +

Overall

5

0.19

Fixed

0.56 (0.41,0.78)

0.0006

Caucasian

2

0.36

Fixed

0.56 (0.31,1.01)

0.06

Asian

2

0.06

Random

0.48 (0.21,1.12)

0.09

Hospital-based

3

0.55

Fixed

0.64 (0.42,0.97)

0.03

Population-based

2

0.05

Random

0.54 (0.16,1.87)

0.33

High quality

4

0.13

Fixed

0.59 (0.41,0.85)

0.004