Skip to main content

Table 3 Association between CDKN2A/2B (rs10811661), SLC30A8 (rs13266634), and TCF7L2 (rs7903146) genotypes and quantitative traits among Thai patients with T2D

From: Impact of KCNQ1, CDKN2A/2B, CDKAL1, HHEX, MTNR1B, SLC30A8, TCF7L2, and UBE2E2 on risk of developing type 2 diabetes in Thai population

Clinical characteristics

CDKN2A/2B (rs10811661) genotypes

SLC30A8 (rs13266634) genotypes

TCF7L2 (rs7903146) genotypes

T/T

T/C

C/C

P

C/C

C/T

T/T

P

C/C

C/T + TT

P

Number of patients

228

220

52

–

172

242

86

–

429

71

–

Weight (kg)

68.99 ± 13.96

67.42 ± 13.73

65.01 ± 14.28

0.250

66.38 ± 14.78

66.38 ± 14.78

66.38 ± 14.78

0.867

67.58 ± 13.60

68.83 ± 15.45

0.172

Waist circumference (cm)

89.34 ± 11.32

89.39 ± 11.69

92.59 ± 11.04

0.007

89.55 ± 11.58

89.79 ± 10.82

89.87 ± 12.75

0.506

89.66 ± 11.30

89.84 ± 12.27

0.861

Waist-to-hip ratio

0.89 ± 0.07

0.91 ± 0.08

0.92 ± 0.11

0.023

0.91 ± 0.07

0.90 ± 0.08

0.90 ± 0.08

0.263

0.90 ± 0.08

0.90 ± 0.080

0.334

BMI (kg/m2)

27.60 ± 5.06

27.07 ± 4.99

26.82 ± 5.075

0.442

26.65 ± 5.15

27.62 ± 4.72

27.59 ± 5.38

0.273

27.27 ± 5.067

27.14 ± 4.71

0.736

SBP (mmHg)

133.60 ± 19.99

134.21 ± 17.58

143.52 ± 23.29

0.746

134.94 ± 18.56

134.44 ± 19.30

136.47 ± 21.82

0.740

135.25 ± 19.64

132.98 ± 18.15

0.800

DBP (mmHg)

78.84 ± 10.72

79.42 ± 9.87

80.75 ± 11.65

0.228

79.95 ± 10.16

78.56 ± 10.85

80.18 ± 9.89

0.348

79.43 ± 10.62

78.87 ± 9.21

0.469

FPG (mmol/l)

9.27 (7.05, 12.49)

8.16 (6.38, 11.88)

7.79 (6.33, 10.68)

0.244

8.33 (6.64, 11.62)

8.49 (6.38, 12.93)

8.77 (6.84, 11.94)

0.164

8.49 (6.50, 12.25)

8.55 (6.94, 8.55)

0.721

HbA1c (mmol/mol)

59.05 (49.70, 78.92)

56.30 (48.6, 71.6)

53.00 (44.82, 77.3)

0.683

56.30 (48.6, 71.6)

57.40 (49.7, 76.5)

59.05 (48.32, 78.10)

0.018

57.40 (48.60, 74.9)

56.30 (47.50, 56.30)

0.535

TC (mmol/l)

202.96 ± 53.19

197.52 ± 51.12

195.80 ± 60.28

0.748

197.40 ± 55.56

199.65 ± 51.20

208.33 ± 55.57

0.853

200.65 ± 54.08

198.00 ± 49.65

0.592

TG (mmol/l)

1.46 (1.03, 2.06)

1.50 (1.18, 2.11)

1.64 (1.17, 2.06)

0.197

1.43 (1.02, 2.05)

1.51 (1.14, 2.08)

1.51 (1.18, 2.26)

0.664

1.52 (1.15, 2.10)

1.32 (1.06, 1.32)

0.600

LDL-C (mmol/l)

2.22 (1.39, 3.85)

2.15 (1.30, 3.50)

1.47 (1.10, 2.87)

0.943

1.89 (1.34, 3.64)

2.38 (1.22, 3.78)

2.22 (1.37, 3.71)

0.854

2.17 (1.33, 3.68)

1.71 (1.16, 1.71)

0.741

HDL-C (mmol/l)

1.58 (1.14, 2.21)

1.63 (1.19, 2.265)

1.78 (1.44, 2.32)

0.965

1.64 (1.17, 2.24)

1.61 (1.19, 2.17)

1.55 (1.14, 2.50)

0.464

1.60 (1.16, 2.18)

1.81 (1.34, 1.81)

0.023

  1. Data presented as mean ± standard deviation or median and interquartile range
  2. P-values were calculated using linear regression after adjusting for age, gender, BMI, and medication, as appropriate. FPG, HbA1c, TG, LDL-C, and HDL-C values were log-transformed to improve normality before regression analysis
  3. Abbreviations: T2D type 2 diabetes, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, HbA 1c glycated hemoglobin, TC, total cholesterol, TG, triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol
Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us