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Table 16 Chi-square analysis of GJB2 variants among the four groups in our study

From: Role of DFNB1 mutations in hereditary hearing loss among assortative mating hearing impaired families from South India

S. No.

Group

GJB2 Positive Alleles

GJB2 Negative Alleles

Total Alleles

Percentage (%)

1

DXD-Both Affected Partners

Observed (O)

125

111

236

52.96

Expected (E)

85.01

150.99

  

2

DXN- Affected Partners

Observed (O)

42

50

92

45.65

Expected (E)

33.14

58.86

  

3

DXN-Normal Hearing Partners

Observed (O)

19

67

86

22.09

Expected (E)

30.98

55.02

  

4

Control

Observed (O)

82

248

330

24.85

Expected (E)

124.88

205.12

  
 

TOTAL

268

476

744

 
 

Chi-Square Value

( Σ(O-E)2/E)

58.21 (P< 0.001)