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Table 3 Genotype and allele frequencies for PsA patients and controls before and after stratification for race (Indians and Caucasians)

From: MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis

Frequency, n (%) Controls PsA patients p value RR (95% CI) OR (95% CI)
Unstratified: Indians + Caucasians (PsA patients: n = 116 and controls: n = 100)
 Genotype, n (%)
 GG 52 (52) 43 (37.07) 0.0595a1  
 GC 44 (44) 63 (54.31)
 CC 4 (4) 10 (8.62)
 GC + CC 48 (48) 73 (62.93) 0.0290b 1.38 (1.04–1.84) 1.84 (1.07–3.17)
 Allele, n (%)
 G 148 (74) 149 (64.22) 0.0295c 1.29 (1.02–1.65) 1.59 (1.05–2.40)
 C 52 (26) 83 (35.78)
Stratified: Indians (PsA patients: n = 84 and controls: n = 62)
 Genotype, n (%)
 GG 37 (59.68) 31 (36.90) 0.0241a2  
 GC 22 (35.48) 46 (54.76)
 CC 3 (4.84) 7 (8.33)
 GC + CC 25 (40.32) 53 (63.10) 0.0075b 1.70 (1.15–2.51) 2.53 (1.29–4.96)
 Allele, n (%)
 G 96 (77.41) 108 (64.29) 0.0200c 1.48 (1.05–2.08) 1.91 (1.13–3.22)
 C 28 (22.58) 60 (35.71)
Stratified: Caucasians (PsA patients: n = 32 and controls: n = 38)
 Genotype, n (%)
 GG 15 (39.47) 12 (37.50) 0.4793a3  
 GC 22 (57.89) 17 (53.13)
 CC 1 (2.63) 3 (9.38)
 GC + CC 23 (60.52) 20 (62.5) 0.9383b 1.04 (0.67–1.61) 1.09 (0.41–2.86)
 Allele, n (%)
 G 52 (68.42) 41 (64.06) 0.5955c 1.10 (0.78–1.53) 1.22 (0.60–2.46)
 C 24 (31.58) 23 (35.04)
  1. CI confidence interval, DF degrees of freedom, RR relative risk, OR odds ratio, PsA psoriatic arthritis, χ2 Chi-squared test
  2. a1, a2, a3Chi squared p value (controls genotypes vs. PsA patients genotypes) (a1 χ2 = 5.644, 2 DF; a2 χ2 = 7.454, 2 DF; a3 χ2 = 1.471, 2 DF). bFisher’s exact test p value (GG vs. GC + CC genotypes). cFisher’s exact test p value (controls G and C alleles vs. PsA patients G and C alleles). A p < 0.05 was considered as being significant