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Table 2 Potential prediabetes or T2DM-associated UCP2 and UCP3 polymorphisms

From: UCP2 and UCP3 variants and gene-environment interaction associated with prediabetes and T2DM in a rural population: a case control study in China

Genotype

NGT

prediabetes

T2DM

pHEW

Prediabetes

T2DM

 

OR

p

aORa

Pa

OR

p

aORa

pa

UCP2

 rs660339

  GG

142 (35.7)

136 (35.5)

132 (34.1)

0.751

1

 

1

 

1

 

1

 

  GA

194 (48.7)

169 (44.1)

191 (49.4)

 

0.91 (0.66,1.24)

0.553

0.90 (0.66,1.24)

0.534

1.06 (0.78,1.44)

0.716

1.05 (0.76,1.45)

0.763

  AA

62 (15.6)

78 (20.4)

64 (16.5)

 

1.31 (0.87,1.98)

0.190

1.32 (0.87,2.00)

0.185

1.11 (0.73,1.69)

0.627

1.11 (0.72,1.71)

0.641

  G

478 (60.1)

441 (57.6)

455 (58.8)

         

  Additive model

(AA vs GA vs GG)

    

1.11 (0.91,1.35)

0.325

0.95 (0.63,1.43)

0.798

1.05 (0.86,1.29)

0.614

1.05 (0.86,1.29)

0.640

  Recessive model

(AA vs GA + GG)

    

1.39 (0.96,2.00)

0.082

1.40 (0.97,2.04)

0.076

1.07 (0.73,1.57)

0.714

1.08 (0.73,1.60)

0.710

  Dominant model (GA + AA vs GG)

    

1.01 (0.75,1.35)

0.961

1.00 (0.75,1.35)

0.978

1.07 (0.80,1.44)

0.645

1.07 (0.79,1.44)

0.686

UCP3

 rs7930460

  AA

195 (49.1)

185 (48.1)

194 (49.4)

0.440

1

 

1

 

1

 

1

 

  AG

171 (43.1)

156 (40.5)

167 (42.5)

 

0.96 (0.72,1.29)

0.795

0.96 (0.71,1.29)

0.776

0.98 (0.73,1.31)

0.901

0.99 (0.73,1.34)

0.954

  GG

31 (7.8)

44 (11.4)

32 (8.1)

 

1.50 (0.91,2.47)

0.116

1.43 (0.86,2.38)

0.173

1.04 (0.61,1.77)

0.892

1.02 (0.59,1.77)

0.939

  A

561 (70.7)

526 (68.3)

555 (70.6)

         

  Additive model

(GG vs AG vs AA)

    

1.12 (0.90,1.39)

0.315

1.10 (0.88,1.37)

0.403

1.00 (0.81,1.24)

0.985

1.00 (0.80,1.25)

0.990

  Recessive model

(GG vs AG + AA)

    

1.52 (0.94,2.47)

0.087

1.46 (0.89,2.38)

0.134

1.05 (0.63,1.75)

0.862

1.03 (0.60,1.75)

0.924

  Dominant model

(GG + AG vs AA)

    

1.04 (0.79,1.38)

0.765

1.03 (0.78,1.37)

0.839

0.99 (0.75,1.31)

0.945

1.00 (0.75,1.33)

0.974

 rs15763

  GG

281 (72.8)

294 (77.8)

298 (78.0)

<0.001

1

 

1

 

1

 

1

 

  GA

39 (10.1)

32 (8.5)

29 (7.6)

 

0.78 (0.48,1.29)

0.336

0.783 (0.47,1.23)

0.342

0.70 (0.42,1.17)

0.170

0.67 (0.40,1.13)

0.136

  AA

66 (17.1)

52 (13.8)

55 (14.4)

 

0.75 (0.51,1.12)

0.163

0.753 (0.50,1.13)

0.169

0.79 (0.53,1.16)

0.230

0.77 (0.51,1.15)

0.201

  G

601 (77.8)

620 (82.0)

625 (81.8)

         

  Additive model

(AA vs GA vs GG)

    

0.86 (0.71,1.04)

0.123

0.86 (0.71,1.05)

0.129

0.87 (0.72,1.05)

0.142

0.85 (0.70,1.04)

0.117

  Recessive model

(AA vs GA + GG)

    

0.77 (0.52,1.15)

0.202

0.77 (0.52,1.16)

0.210

0.82 (0.55,1.20)

0.305

0.80 (0.53,1.20)

0.279

  Dominant model

(GA + AA vs GG)

    

0.77 (0.55,1.06)

0.111

0.76 (0.55,1.07)

0.117

0.75 (0.54,1.05)

0.094

0.73 (0.52,1.03)

0.072

 rs1800849

  GG

192 (48.2)

173 (44.7)

180 (45.7)

0.305

1

 

1

 

1

 

1

 

  GA

175 (44.0)

165 (42.6)

182 (46.2)

 

1.05 (0.78,1.41)

0.764

1.05 (0.78,1.41)

0.773

1.11 (0.83,1.48)

0.484

1.12 (0.83,1.52)

0.447

  AA

31 (7.8)

49 (12.7)

32 (8.1)

 

1.75 (1.07,2.88)

0.026

1.68 (1.02,2.78)

0.043

1.10 (0.65,1.88)

0.724

1.06 (0.61,1.83)

0.842

  G

559 (70.2)

511 (66.0)

542 (68.8)

         

  Additive model

(AA vs GA vs GG)

    

1.22 (0.98,1.51)

0.071

1.20 (0.97,1.50)

0.098

1.07 (0.86,1.33)

0.527

1.07 (0.85,1.33)

0.581

  Recessive model

(AA vs GA + GG)

    

1.72 (1.07,2.76)

0.025

1.64 (1.02,2.66)

0.043

1.05 (0.63,1.75)

0.863

1.00 (0.59,1.70)

0.995

  Dominant model

(AA+GA vs GG)

    

1.15 (0.87,1.53)

0.320

1.14 (0.86,1.52)

0.361

1.11 (0.84,1.47)

0.471

1.11 (0.83,1.48)

0.473

  1. OR odds ratio, T2DM type 2 diabetes, UCP uncoupling proteins
  2. Bold denotes significant at p-value < 0.05 or marginal significant
  3. aAdjusted for sex, age, regular exercise, income, excessive drinking, smoking, hypertension and overweight
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BMC Medical Genetics

ISSN: 1471-2350

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