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Table 3 Association of the NGF and NGFR genes SNPs with IS risk under different models

From: Involvement of polymorphisms of the nerve growth factor and its receptor encoding genes in the etiopathogenesis of ischemic stroke

Gene SNP (M/m) Groups Genotypes (number/frequency) Model OR (95%CI) P nom
MM Mm mm
NGF rs6330 (C/T) IS patients 60 (0.35) 82 (0.48) 28 (0.175) multiplicative 2.65 (1.996–3.5) 7.3E-12
dominant 3.39 (2.35–4.89) 4.8E-11
Controls 130 (0.65) 58 (0.29) 12 (0.06) recessive 3.07 (1.65–5.72) 0.0002
additive 3.409 (2.3–5.054) < 0.0001
NGF rs4839435 (G/A) IS patients 73 (0.43) 77 (0.45) 20 (0.12) multiplicative 1.05 (0.81–1.37) 0.45
dominant 0.98 (0.69–1.4) 1
Controls 85 (0.425) 97 (0.485) 18 (0.09) recessive 1.35 (0.76–2.39) 0.3
additive 0.851 (0.58–1.24) 0.4
NGFR rs11466155 (C/T) IS patients 86 (0.505) 72 (0.424) 12 (0.071) multiplicative 1.11 (0.84–1.46) 0.48
dominant 1.19 (0.84–1.69) 0.32
Controls 110 (0.55) 75 (0.375) 15 (0.075) recessive 1.06 (0.54–2.07) 0.86
additive 1.791 (1.15–2.79) 0.011
NGFR rs2072446 (C/T) IS patients 68 (0.4) 79 (0.465) 23 (0.135) multiplicative 1.43 (1.09–1.86) 0.008
dominant 1.68 (1.18–2.39) 0.004
Controls 105 (0.525) 73 (0.365) 22 (0.11) recessive 1.3 (0.76–2.23) 0.3
additive 2.327 (1.56–3.48) < 0.0001
NGFR rs734194 (T/G) IS patients 138 (0.81) 30 (0.18) 2 (0.01) multiplicative 3.36 (2.36–4.78) 2.3E-12
dominant 3.62 (2.42–5.42) 1.7E-10
Controls 109 (0.545) 73 (0.365) 18 (0.09) recessive 7.95 (2.35–26.89) 9.7E-5
additive 0.182 (0.11–0.32) < 0.0001
  1. “M/m” indicates major/minor alleles; multiplicative model indicates “M vs. m”; dominant model indicates “Mm + mm vs. MM”; recessive model indicates “MM + Mm vs. mm”; additive model indicates “MM vs. Mm vs. mm”