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Table 3 Association of the NGF and NGFR genes SNPs with IS risk under different models

From: Involvement of polymorphisms of the nerve growth factor and its receptor encoding genes in the etiopathogenesis of ischemic stroke

Gene SNP (M/m)

Groups

Genotypes (number/frequency)

Model

OR (95%CI)

P nom

MM

Mm

mm

NGF rs6330 (C/T)

IS patients

60 (0.35)

82 (0.48)

28 (0.175)

multiplicative

2.65 (1.996–3.5)

7.3E-12

dominant

3.39 (2.35–4.89)

4.8E-11

Controls

130 (0.65)

58 (0.29)

12 (0.06)

recessive

3.07 (1.65–5.72)

0.0002

additive

3.409 (2.3–5.054)

< 0.0001

NGF rs4839435 (G/A)

IS patients

73 (0.43)

77 (0.45)

20 (0.12)

multiplicative

1.05 (0.81–1.37)

0.45

dominant

0.98 (0.69–1.4)

1

Controls

85 (0.425)

97 (0.485)

18 (0.09)

recessive

1.35 (0.76–2.39)

0.3

additive

0.851 (0.58–1.24)

0.4

NGFR rs11466155 (C/T)

IS patients

86 (0.505)

72 (0.424)

12 (0.071)

multiplicative

1.11 (0.84–1.46)

0.48

dominant

1.19 (0.84–1.69)

0.32

Controls

110 (0.55)

75 (0.375)

15 (0.075)

recessive

1.06 (0.54–2.07)

0.86

additive

1.791 (1.15–2.79)

0.011

NGFR rs2072446 (C/T)

IS patients

68 (0.4)

79 (0.465)

23 (0.135)

multiplicative

1.43 (1.09–1.86)

0.008

dominant

1.68 (1.18–2.39)

0.004

Controls

105 (0.525)

73 (0.365)

22 (0.11)

recessive

1.3 (0.76–2.23)

0.3

additive

2.327 (1.56–3.48)

< 0.0001

NGFR rs734194 (T/G)

IS patients

138 (0.81)

30 (0.18)

2 (0.01)

multiplicative

3.36 (2.36–4.78)

2.3E-12

dominant

3.62 (2.42–5.42)

1.7E-10

Controls

109 (0.545)

73 (0.365)

18 (0.09)

recessive

7.95 (2.35–26.89)

9.7E-5

additive

0.182 (0.11–0.32)

< 0.0001

  1. “M/m” indicates major/minor alleles; multiplicative model indicates “M vs. m”; dominant model indicates “Mm + mm vs. MM”; recessive model indicates “MM + Mm vs. mm”; additive model indicates “MM vs. Mm vs. mm”