Gene SNP (M/m) | Groups | Genotypes (number/frequency) | Model | OR (95%CI) | P nom | ||
---|---|---|---|---|---|---|---|
MM | Mm | mm | |||||
NGF rs6330 (C/T) | IS patients | 60 (0.35) | 82 (0.48) | 28 (0.175) | multiplicative | 2.65 (1.996–3.5) | 7.3E-12 |
dominant | 3.39 (2.35–4.89) | 4.8E-11 | |||||
Controls | 130 (0.65) | 58 (0.29) | 12 (0.06) | recessive | 3.07 (1.65–5.72) | 0.0002 | |
additive | 3.409 (2.3–5.054) | < 0.0001 | |||||
NGF rs4839435 (G/A) | IS patients | 73 (0.43) | 77 (0.45) | 20 (0.12) | multiplicative | 1.05 (0.81–1.37) | 0.45 |
dominant | 0.98 (0.69–1.4) | 1 | |||||
Controls | 85 (0.425) | 97 (0.485) | 18 (0.09) | recessive | 1.35 (0.76–2.39) | 0.3 | |
additive | 0.851 (0.58–1.24) | 0.4 | |||||
NGFR rs11466155 (C/T) | IS patients | 86 (0.505) | 72 (0.424) | 12 (0.071) | multiplicative | 1.11 (0.84–1.46) | 0.48 |
dominant | 1.19 (0.84–1.69) | 0.32 | |||||
Controls | 110 (0.55) | 75 (0.375) | 15 (0.075) | recessive | 1.06 (0.54–2.07) | 0.86 | |
additive | 1.791 (1.15–2.79) | 0.011 | |||||
NGFR rs2072446 (C/T) | IS patients | 68 (0.4) | 79 (0.465) | 23 (0.135) | multiplicative | 1.43 (1.09–1.86) | 0.008 |
dominant | 1.68 (1.18–2.39) | 0.004 | |||||
Controls | 105 (0.525) | 73 (0.365) | 22 (0.11) | recessive | 1.3 (0.76–2.23) | 0.3 | |
additive | 2.327 (1.56–3.48) | < 0.0001 | |||||
NGFR rs734194 (T/G) | IS patients | 138 (0.81) | 30 (0.18) | 2 (0.01) | multiplicative | 3.36 (2.36–4.78) | 2.3E-12 |
dominant | 3.62 (2.42–5.42) | 1.7E-10 | |||||
Controls | 109 (0.545) | 73 (0.365) | 18 (0.09) | recessive | 7.95 (2.35–26.89) | 9.7E-5 | |
additive | 0.182 (0.11–0.32) | < 0.0001 |