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Table 3 Allele and genotype frequencies of S100B SNPs in the validation cohort

From: S100B polymorphisms are associated with age of onset of Parkinson’s disease

 

Controls

 

Early onset PD

Late onset PD

p-Valuea

p-Valueb

OR

 

n

Frequency

n

Frequency

n

Frequency

   

rs9722

C

679

0.913

37

0.841

325

0.950

0.005

0.109

3.6 (1.4–9.3)

T

65

0.087

7

0.159

17

0.050

   

CC

312

0.839

16

0.727

157

0.918

0.021

0.277

 

TC

55

0.148

5

0.227

11

0.064

   

TT

5

0.013

1

0.045

3

0.018

   

rs2239574

C

515

0.689

27

0.643

238

0.704

0.415

0.535

1.3 (0.7–2.6)

T

233

0.311

15

0.357

100

0.296

   

CC

172

0.460

9

0.429

86

0.509

0.731

0.635

 

TC

171

0.457

9

0.429

66

0.391

   

TT

31

0.083

3

0.143

17

0.101

   

rs881827

C

537

0.718

38

0.864

240

0.702

0.024

0.035

2.7 (1.1–6.6)

T

211

0.282

6

0.136

102

0.298

   

CC

200

0.535

17

0.773

85

0.497

0.051

0.093

 

TC

137

0.366

4

0.182

70

0.409

   

TT

37

0.099

1

0.045

16

0.094

   

rs9984765

T

549

0.736

31

0.705

260

0.760

0.420

0.647

1.3 (0.7–2.7)

C

197

0.264

13

0.295

82

0.240

   

TT

202

0.539

11

0.500

104

0.608

0.587

0.883

 

CT

148

0.395

9

0.409

52

0.304

   

CC

25

0.067

2

0.091

15

0.088

   

rs1051169

C

475

0.656

26

0.591

224

0.663

0.346

0.378

1.4 (0.7–2.6)

G

249

0.344

18

0.409

114

0.337

   

CC

156

0.430

9

0.409

77

0.456

0.469

0.284

 

GC

165

0.455

8

0.364

70

0.414

   

GG

42

0.116

5

0.227

22

0.130

   
  1. Significant (p < 0.05) results are shown in bold. aEarly onset PD (≤50 years) compared to late onset PD (> 50 years). bEarly onset PD compared to controls. cOR (95% confidence interval) for early onset PD compared to controls. P-values were calculated from Chis-square test and ORs were calculated using logistic regression