S100B polymorphisms are associated with age of onset of Parkinson’s disease

BMC Medical Genetics

Table 2 Allele and genotype frequencies of S100B SNPs in the discovery cohort

	Controls		Early onset PD		Late onset PD		p-Value^a	p-Value^b	OR^c
	n	Frequency	n	Frequency	n	Frequency
rs9722
C	782	0.929	147	0.865	626	0.946	2.0 × 10 ⁻⁴	0.006	2.7 (1.6–4.7)
T	60	0.071	23	0.135	36	0.054
CC	365	0.867	64	0.753	296	0.894	0.001	0.026
TC	52	0.124	19	0.224	34	0.103
TT	4	0.010	2	0.024	1	0.003
rs2239574
C	559	0.661	118	0.686	463	0.704	0.654	0.522	1.1 (0.8–1.6)
T	287	0.339	54	0.314	195	0.296
CC	188	0.444	38	0.442	168	0.511	0.202	0.320
TC	183	0.433	42	0.488	127	0.386
TT	52	0.123	6	0.070	34	0.103
rs881827
C	629	0.740	130	0.756	464	0.714	0.274	0.665	1.2 (0.8–1.8)
T	221	0.260	42	0.244	186	0.286
CC	236	0.555	48	0.558	166	0.511	0.468	0.615
TC	157	0.369	34	0.395	132	0.406
TT	32	0.075	4	0.047	27	0.083
rs9984765
T	649	0.774	116	0.674	508	0.772	0.008	0.005	1.6 (1.1–2.4)
C	189	0.226	56	0.326	150	0.228
TT	263	0.628	38	0.442	197	0.599	0.028	0.004
CT	123	0.294	40	0.465	114	0.347
CC	33	0.079	8	0.093	18	0.055
rs1051169
C	568	0.688	104	0.605	453	0.688	0.037	0.035	1.4 (1.0–2.0)
G	258	0.312	68	0.395	205	0.312
CC	206	0.499	34	0.395	157	0.477	0.073	0.138
GC	156	0.378	36	0.419	139	0.422
GG	51	0.123	16	0.186	33	0.100

Significant (p < 0.05) results are shown in bold. ^aEarly onset PD (≤50 years) compared to late onset PD (> 50 years). ^bEarly onset PD compared to controls. ^cOR (95% confidence interval) for early onset PD compared to controls. P-values were calculated from Chis-square test and ORs were calculated using logistic regression

ISSN: 1471-2350