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Table 2 Allele and genotype frequencies of S100B SNPs in the discovery cohort

From: S100B polymorphisms are associated with age of onset of Parkinson’s disease

  Controls   Early onset PD Late onset PD p-Valuea p-Valueb ORc
  n Frequency n Frequency n Frequency    
rs9722
C 782 0.929 147 0.865 626 0.946 2.0 × 10 −4 0.006 2.7 (1.6–4.7)
T 60 0.071 23 0.135 36 0.054    
CC 365 0.867 64 0.753 296 0.894 0.001 0.026  
TC 52 0.124 19 0.224 34 0.103    
TT 4 0.010 2 0.024 1 0.003    
rs2239574
C 559 0.661 118 0.686 463 0.704 0.654 0.522 1.1 (0.8–1.6)
T 287 0.339 54 0.314 195 0.296    
CC 188 0.444 38 0.442 168 0.511 0.202 0.320  
TC 183 0.433 42 0.488 127 0.386    
TT 52 0.123 6 0.070 34 0.103    
rs881827
C 629 0.740 130 0.756 464 0.714 0.274 0.665 1.2 (0.8–1.8)
T 221 0.260 42 0.244 186 0.286    
CC 236 0.555 48 0.558 166 0.511 0.468 0.615  
TC 157 0.369 34 0.395 132 0.406    
TT 32 0.075 4 0.047 27 0.083    
rs9984765
T 649 0.774 116 0.674 508 0.772 0.008 0.005 1.6 (1.1–2.4)
C 189 0.226 56 0.326 150 0.228    
TT 263 0.628 38 0.442 197 0.599 0.028 0.004  
CT 123 0.294 40 0.465 114 0.347    
CC 33 0.079 8 0.093 18 0.055    
rs1051169
C 568 0.688 104 0.605 453 0.688 0.037 0.035 1.4 (1.0–2.0)
G 258 0.312 68 0.395 205 0.312    
CC 206 0.499 34 0.395 157 0.477 0.073 0.138  
GC 156 0.378 36 0.419 139 0.422    
GG 51 0.123 16 0.186 33 0.100    
  1. Significant (p < 0.05) results are shown in bold. aEarly onset PD (≤50 years) compared to late onset PD (> 50 years). bEarly onset PD compared to controls. cOR (95% confidence interval) for early onset PD compared to controls. P-values were calculated from Chis-square test and ORs were calculated using logistic regression