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Table 2 Distribution of genotype and allele frequencies of the PGR Alu insertion

From: The Alu-insertion progesterone receptor gene polymorphism is not associated with breast cancer: a meta-analysis

Author

Genotype distribution

P HWE

Allele frequency

Cases, n

Controls, n

Cases, %

Controls, %

T1T1

T1T2

T2T2

T1T1

T1T2

T2T2

T1

T2

T1

T2

Manolitsas [36]

229

61

2

162

54

4

0.8375

88.9

11.1

85.9

14.1

Lancaster [25]

55

12

1

79

18

4

0.0390

89.7

10.3

87.1

12.9

Wang-Gohrke [23]

426

128

5

393

144

17

0.3945

87.7

12.3

83.9

16.1

Fabjani [24]

119

32

4

78

28

0

0.1172

87.1

12.9

86.8

13.2

Donaldson [26]

17

5

1

41

16

3

0.3965

84.8

15.2

81.7

18.3

Donaldson [26]

56

5

0

73

8

0

0.6401

95.9

4.1

95.1

4.9

Linhares [37]

31

18

1

31

17

1

0.4416

80.0

20.0

80.6

19.4

Romano [38]

123

41

3

22

7

2

0.2075

85.9

14.1

82.3

17.7

Surekha [39]

241

7

2

242

7

0

0.8220

97.8

2.2

98.6

1.4

Gallegos-Arreola [22]

360

103

18

176

33

0

0.2153

85.6

14.4

92.1

7.9

  1. Note: PHWE, the P value of Hardy-Weinberg equilibrium test in the genotype distribution of controls; T1/T1, homozygotes without the 306-bp insertion; T1/T2, heterozygotes with the insertion; T2/T2, homozygotes with the insertion