Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study

Table 4 Relationship between rs1485175 and NIHL layered by CNE

Environmental factor	Genotype	Case		Control		OR (95% CI) ^*	p/p_bon ^†
		n	%	n	%
CNE, dB (A)
< 97	TT	44	30.8	81	29.5	1	0.846/0.423
	TC	74	51.7	138	50.2	1.023 (0.700, 1.496)	0.906/0.453
	CC	25	17.5	56	20.4	0.895 (0.546, 1.469)	0.662/0.331
> 97	TT	61	40.9	91	29.4	1	0.047/0.024
	TC	65	43.6	138	44.7	0.784 (0.550, 1.118)	0.179/0.090
	CC	23	15.4	80	25.9	0.550 (0.340, 0.891)	0.014/0.007

The interaction between genes and the environment (CNE) analyzed by layering
^*Height, smoking, drinking, and hypertension are adjusted
^†The statistically significant p values are adjusted by Bonferroni correction through 0.05/2 (2 groups layered by CNE) and it is statistically significant if p_bon < 0.025

ISSN: 1471-2350