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Table 1 Time course of the phenotype in the proband

From: Non-syndromic cardiac progeria in a patient with the rare pathogenic p.Asp300Asn variant in the LMNA gene

Year Age Phenotype Intervention
1994 29 Acute myocardial infarction Coronary Artery bypass surgery
1995 30 Mitral regurgitation Mitral valve repair surgery
2001 36 Acute myocardial infarction Percutaneous coronary interventions
2001 36 Sick Sinus Syndrome Permanent pacemaker implantation
2001 36 Aortic and mitral valves stenosis/regurgitation Aortic valve replacement Mitral valve replacement
2003 38 Atrial flutter Catheter ablation
2004 39 Acute myocardial infarction Percutaneous coronary interventions, placement of 2 stents
2004 39 Refractory right heart failure with severe tricuspid regurgitation Transplant evaluation
2005 40 Death