Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies

Table 6 The results of meta-analysis for various genotype models

Genetic model			Heterogeneity test							Test of Association					Publication bias
Name	Explanation	Ethnicity	Q value	d.f.	I-squared	Tau-squared	P Value	Heterogeneity	Effect model	Pooled OR	95% CI	Z value	P value	Statistical significance	Publication bias
Allele model	G vs. A	Caucasian	17.38	6	65.5%	0.0493	0.008	Yes	Random	0.985	[0.797, 1.217]	0.14	0.888	No	No
		Asian	14.90	7	53.0%	0.0564	0.037	Yes	Random	1.100	[0.871, 1.390]	0.80	0.421	No
		Total	34.85	14	59.8%	0.0487	0.002	Yes	Random	1.037	[0.890, 1.210]	0.47	0.640	No
Homozygote model	GG vs. AA	Caucasian	5.60	6	0.0%	NA	0.469	No	Random	1.119	[0.731, 1.714]	0.52	0.605	No	No
		Asian	10.22	7	31.5%	NA	0.176	No	Random	1.146	[0.743, 1.767]	0.62	0.538	No
		Total	15.81	14	11.4%	NA	0.325	No	Random	1.118	[0.830, 1.506]	0.74	0.462	No
Heterozygote model	AG vs. AA	Caucasian	16.71	6	64.1%	0.0575	0.010	Yes	Random	0.983	[0.780, 1.237]	0.15	0.882	No	No
		Asian	15.58	7	55.1%	0.1296	0.029	Yes	Random	1.433	[1.015, 2.023]	2.04	0.041	No
		Total	42.72	14	67.2%	0.1017	0.000	Yes	Random	1.155	[0.935, 1.427]	1.34	0.181	No
Dominant model	AG + GG vs. AA	Caucasian	41.43	8	80.7%	0.1518	0.000	Yes	Random	1.185	[0.882, 1.593]	1.13	0.259	No	No
		Asian	16.65	7	58.0%	0.1310	0.020	Yes	Random	1.379	[0.983, 1.934]	1.86	0.063	No
		Total	63.64	16	74.9%	0.1467	0.000	Yes	Random	1.261	[1.008, 1.578]	2.03	0.042	No
Recessive model	GG vs. AA + AG	Caucasian	5.24	6	0.0%	NA	0.513	No	Random	1.142	[0.746, 1.747]	0.61	0.542	No	No
		Asian	6.21	7	0.0%	NA	0.516	No	Random	0.919	[0.673, 1.255]	0.53	0.595	No
		Total	12.06	14	0.0%	NA	0.602	No	Random	0.991	[0.771, 1.275]	0.07	0.946	No

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