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Fig. 3 | BMC Medical Genetics

Fig. 3

From: Characterization of a novel KCNJ2 sequence variant detected in Andersen-Tawil syndrome patients

Fig. 3

Representative currents and current/voltage relations recorded from HEK293 cells expressing different Kir2.1 constructs. a Current traces of HEK293 cells expressing WT Kir2.1 channels or the Y145C mutant alone. WT and mutant were also co-transfected in a 1/1 or 1/3 ratio (wt/mut). b Mean current/voltage relations (± standard deviation) from measurements as in a from HEK293 cells expressing WT (), mutant () or a 1:1 (▲) or 1:3 mixture () of WT and mutant channels. The mean value of the WT current at −120 mV is significantly higher (p < 0.01, **) than any of the other constructs. At −120 mV, co-expression of WT and mutant generates an inward current, which is significantly higher (p < 0.05; *) than those measured with the mutant channel only

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