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Table 2 Distribution of the AGT, AGTR1, and ACE genotypes and the frequency of alleles in the study population

From: Renin-angiotensin system gene polymorphisms and high blood pressure in Lithuanian children and adolescents

Characteristics

Boys

Girls

HBP

NBP

HBP

NBP

AGT, M235 T genotypes, n (%)

 MM

45 (27.3)

49 (27.1)

28 (27.2)

65 (26.7)

 MT

82 (49.7)

77 (42.5)

57 (55.3)

125 (51.2)

 TT

38 (23.0)

55 (30.4)

18 (17.5)

54 (22.1)

 

χ2 = 2.70, p = 0.259

χ2 = 0.99, p = 0.607

AGT, M235 T alleles, frequency

 M

0.52

0.48

0.55

0.52

 T

0.48

0.52

0.45

0.48

 

χ2 = 0.99, p = 0.321

χ2 = 0.39, p = 0.531

AGTR1, A1166C genotypes, n (%)

 AA

87 (52.4)

85 (47.2)

59 (56.2)

123 (50.2)

 AC

67 (40.4)

77 (42.8)

39 (37.1)

107 (43.7)

 CC

12 (7.2)

18 (10.0)

7 (6.7)

15 (6.1)

 

χ2 = 1.35, p = 0.508

χ2 = 1.29, p = 0.524

AGTR1, A1166C alleles, frequency

 A

0.73

0.69

0.75

0.72

 C

0.27

0.31

0.25

0.28

 

χ2 = 1.32, p = 0.251

χ2 = 0.55, p = 0.450

ACE, ID genotypes, n (%)

 II

34 (20.6)

58 (31.6)

25 (24.0)

65 (26.4)

 ID

94 (57.0)

79 (42.9)

55 (52.9)

126 (51.2)

 DD

37 (22.4)

47 (25.5)

24 (23.1)

55 (22.4)

 

χ2 = 7.74, p = 0.021

χ2 = 0.22, p = 0.897

ACE, ID alleles, frequency

 I

0.49

0.53

0.50

0.52

 D

0.51

0.47

0.50

0.48

 

χ2 = 1.06, p = 0.304

χ2 = 0.14, p = 0.707

  1. Comparisons between groups were performed by applying the χ2 test
  2. Abbreviations: NBP normal blood pressure, HBP high blood pressure, AGT angiotensinogen, AGTR1 angiotensin II receptor 1, ACE angiotensin-converting enzyme
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BMC Medical Genetics

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